Results 51 to 60 of about 70,966 (297)

Separation structure of positive radial solutions of a semilinear elliptic equation in Rn

, 2003
This paper deals with the following inter-connected subjects: (i) Separation of positive radial solutions is studied for the elliptic equation Δu+K(|x|)up=0 in Rn. In case r−ℓK(r) is decreasing, with suitable decay rate, to a positive constant as r→∞ for
Bae, Soohyun, Soohyun Bae
core   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

On existence and asymptotic behavior of solutions of elliptic equations with nearly critical exponent and singular coefficients

Electronic Journal of Qualitative Theory of Differential Equations, 2021
In this paper we study the existence and asymptotic behavior of solutions of $$-\Delta u=\mu\frac{u}{|x|^{2}}+|x|^{\alpha}u^{p(\alpha)-1-\varepsilon},\qquad u>0 \ \text{in}\ B_{R}(0)$$ with Dirichlet boundary condition.
Shiyu Li, Gongming Wei, Xueliang Duan
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Radial solutions for a nonlocal boundary value problem

Boundary Value Problems, 2006
We consider the boundary value problem for the nonlinear Poisson equation with a nonlocal term −Δu=f(u,∫Ug(u)), u|∂U=0. We prove the existence of a positive radial solution when f grows linearly in u, using Krasnoselskiiés fixed ...
Luís Sanchez, Ricardo Enguiça   +1 more
doaj   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Localized radial solutions for a nonlinear p-Laplacian equation in $R^N$

Electronic Journal of Qualitative Theory of Differential Equations, 2008
We establish the existence of radial solutions to the p-Laplacian equation $ \Delta_p u + f(u)=0 $ in $\mathbb {R^N}$, where $f$ behaves like $|u|^{q-1}u$ when $u$ is large and $f(u) < 0$ for small positive $u$. We show that for each nonnegative integer
S. Pudipeddi
doaj   +1 more source

A system of equations involving the fractional p-Laplacian and doubly critical nonlinearities

Advanced Nonlinear Studies, 2023
This article deals with existence of solutions to the following fractional pp-Laplacian system of equations: (−Δp)su=∣u∣ps*−2u+γαps*∣u∣α−2u∣v∣βinΩ,(−Δp)sv=∣v∣ps*−2v+γβps*∣v∣β−2v∣u∣αinΩ,\left\{\begin{array}{l}{\left(-{\Delta }_{p})}^{s}u={| u| }^{{p}_{s}^{
Bhakta Mousomi, Perera Kanishka, Sk Firoj   +2 more
doaj   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source