Results 161 to 170 of about 1,927,312 (260)

Emergence, persistence, and positive selection of yellow fever virus in Colombia. [PDF]

Front Microbiol
Perez LJ, Perez-Restrepo LS, Ciuoderis K, Usuga J, Moreno I, Vargas V, Arévalo-Arbelaez AJ, Berg MG, Cloherty GA, Hernández-Ortiz JP, Osorio JE.   +10 more
europepmc   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Oncodrive3D: fast and accurate detection of structural clusters of somatic mutations under positive selection. [PDF]

Nucleic Acids Res
Pellegrini S, Dove-Estrella O, Muiños F, Lopez-Bigas N, Gonzalez-Perez A.   +4 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Positive selection on rare variants of IGF1R and BRD4 underlying the cold adaptation of wild boar. [PDF]

Genet Sel Evol
Chen J, Jakovlić I, Sablin M, Xia S, Xu Z, Guo Y, Kuang R, Zhong J, Jia Y, Tran NTT, Yang H, Ma H, Šprem N, Han J, Liu D, Zhao Y, Zhao S.   +16 more
europepmc   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Evidence of positive selection and a novel phylogeny among five subspecies of song sparrow (<i>Melospiza melodia</i>) in Alaska. [PDF]

PeerJ
Oliver Brown CC, Collier KA, Tan DJX, Mills K, Spaulding F, Glenn TC, Pruett C, Winker K.   +7 more
europepmc   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Decoding Positive Selection in Mycobacterium tuberculosis with Phylogeny-Guided Graph Attention Models

Wang L, Campino S, Clark TG, Phelan JE.
europepmc   +1 more source

Addendum: Protein arginine methyltransferase 1 regulates B cell fate after positive selection in the germinal center in mice. [PDF]

J Exp Med
Litzler LC, Zahn A, Dionne KL, Sprumont A, Ferreira SR, Slattery MRF, Methot SP, Patenaude AM, Hébert S, Kabir N, Subramani PG, Jung S, Richard S, Kleinman CL, Di Noia JM.   +14 more
europepmc   +1 more source