Results 131 to 140 of about 13,731,074 (335)

Existence of a positive solution for nonlinear Schrödinger equations with general nonlinearity

open access: yesAdvances in Nonlinear Analysis, 2014
We study the following nonlinear Schrödinger equations: -Δu+V(x)u=f(u)inℝN.$ - \Delta u + V(x) u = f(u) \quad \text{in } {\mathbb {R}^N}. $ The purpose of this paper is to establish the existence of a positive solution under general conditions which are ...
Sato Yohei, Shibata Masataka
doaj   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

open access: yesMolecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

open access: yesMolecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes   +20 more
wiley   +1 more source

Positive solutions for second-order multi-point boundary-value problems at resonance in Banach spaces

open access: yesElectronic Journal of Differential Equations, 2011
In this article, we study the existence and multiplicity of positive solutions for a nonlinear second-order multi-point boundary-value problem at resonance in Banach spaces. The arguments are based upon a specially constructed equivalent equation and
Weihua Jiang, Bin Wang
doaj  

Positive Solutions of an Emden-Fowler Equation

open access: yesJournal of Mathematical Analysis and Applications, 1994
Some new results concerning asymptotic integration and global existence of positive solutions of the Emden-Fowler equation \((r(t)x')' = P(t) | x |^{\nu-1} x\) are given. These results improve well known results of this area. Some applications to certain elliptic problems are given, too.
openaire   +3 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Monotone and convex positive solutions for fourth-order multi-point boundary value problems

open access: yesBoundary Value Problems, 2011
The existence results of multiple monotone and convex positive solutions for some fourth-order multi-point boundary value problems are established. The nonlinearities in the problems studied depend on all order derivatives. The analysis relies on a fixed
Chunfang Shen, Liu Yang, Weiguo Zhang
doaj  

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

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