Results 141 to 150 of about 3,779,631 (328)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Global multiplicity of positive solutions for anisotropic $(p,q)$-Robin boundary value problems with an indefinite potential term

Electronic Journal of Qualitative Theory of Differential Equations
We consider a nonlinear Robin problem driven by the anisotropic $(p,q)$-Laplacian plus an indefinite potential term. In the reaction, we have the competing effects of a parametric concave (sublinear) term perturbed by a superlinear one (concave-convex ...
Eylem Öztürk, Nikolaos Papageorgiou
doaj   +1 more source

Positive solutions of fractional integral equations by the technique of measure of noncompactness. [PDF]

J Inequal Appl, 2017
Nashine HK, Arab R, Agarwal RP, De la Sen M.   +3 more
europepmc   +1 more source

On Existence of Symmetric Positive Solutions for SSBVPs on Time Scales

, 2021
Cansel KUYUMCU, Erbil Çetin
openalex   +2 more sources

Existence of positive periodic solutions for first-order nonlinear differential equations with multiple time-varying delays [PDF]

, 2022
Xiaoling Han, Ceyu Lei
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Positive solutions of a boundary-value problem for a differential equation with damping and actively bounded delayed forcing term

Electronic Journal of Differential Equations, 2006
Sufficient conditions are given for the existence of positive solutions of a boundary-value problem concerning a second-order delay differential equation with damping and forcing term whose the delayed part is an actively bounded function, a ...
George L. Karakostas
doaj  

On the existence of positive solutions for fractional differential inclusions at resonance. [PDF]

Springerplus, 2016
Hu L.
europepmc   +1 more source

BLOW UP OF SOLUTIONS WITH POSITIVE INITIAL ENERGY FOR THE NONLOCAL SEMILINEAR HEAT EQUATION [PDF]

, 2012
Zhong Bo Fang, Lu Sun
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source