Results 51 to 60 of about 457,753 (313)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Positive almost periodic solutions of some delay integral equations

Journal of Differential Equations, 1990
The author studies a class of delay integral equations which arises in models for the spread of epidemics. He shows the existence of positive almost periodic solutions, gives a priori bounds on the set of positive solutions and uniqueness results.
Fink, A.M, Gatica, J.A
openaire   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

POSITIVE SOLUTIONS OF A NONLINEAR INTEGRAL EQUATION FROM BIOMATHEMATICS

Demonstratio Mathematica, 1999
The aim of the paper is to investigate the existence of positive continuous solutions of the nonlinear integral equation \(x(t)= \int^t_{t-\tau} f(s,x(s))ds\), arising in infectious disease. Sufficient conditions are given ensuring the existence of positive periodic continuous solutions of this equation, provided that \(f\) is a continuous function ...
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Existence of Solutions to the Bethe Ansatz Equations for the 1D Hubbard Model: Finite Lattice and Thermodynamic Limit

, 2004
In this work, we present a proof of the existence of real and ordered solutions to the generalized Bethe Ansatz equations for the one dimensional Hubbard model on a finite lattice, with periodic boundary conditions.
Bethe, Essler, Gottlieb, Göhmann, Hubbard, Lieb, Lieb, Pedro S. Goldbaum, Woynarovich, Yang, Yang   +10 more
core   +3 more sources

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Positive solutions of a fourth-order differential equation with integral boundary conditions

Mathematica Bohemica, 2022
The paper is concerned with the fourth-order two-point boundary value problem \[\left\{\begin{array}{l} u''''(t)+f(t,u(t))=0,\,\,\,t\in (0,1),\\ u'(0)=u'(1)=u''(0)=0,\,\,\,u(0)=\alpha[u], \end{array}\right.\leqno(1)\] where \(\alpha[u]=\int_0^1u(t)\,dA(t)\) is the Riemann-Stieltjes integral, \(A:[0,1]\to\mathbb{R}_+\) is a nondecreasing function of ...
Seshadev Padhi, John R. Graef
openaire   +2 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source