Results 61 to 70 of about 457,753 (313)

A variational principle for stationary, axisymmetric solutions of Einstein's equations

, 2005
Stationary, axisymmetric, vacuum, solutions of Einstein's equations are obtained as critical points of the total mass among all axisymmetric and $(t,\phi)$ symmetric initial data with fixed angular momentum.
Bartnik R, Cantor M, Carter B, Horowitz G T, Horowitz G T Flaherty F J, Neugebauer G, Sergio Dain, Szabados L B, Wald R M   +8 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Boltzmann equations for mixtures of Maxwell gases: exact solutions and power like tails

, 2006
We consider the Boltzmann equations for mixtures ofMaxwell gases. It is shown that in certain limiting case the equations admit self-similar solutions that can be constructed in explicit form.
A. Pulvirenti, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, A. V. Bobylev, E. Gabetta, I. M. Gamba, M. H. Ernst, M. Krook, W. Feller   +13 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Positive Solutions for Singular p-Laplacian Fractional Differential System with Integral Boundary Conditions

Abstract and Applied Analysis, 2014
This paper investigates the existence of positive solutions for a class of singular p-Laplacian fractional differential equations with integral boundary conditions.
Liping Wang, Zongfu Zhou, Hui Zhou
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Positive Solutions for Nonlinear Fractional Differential Equations with Boundary Conditions Involving Riemann-Stieltjes Integrals

Abstract and Applied Analysis, 2012
We consider the existence of positive solutions for a class of nonlinear integral boundary value problems for fractional differential equations. By using some fixed point theorems, the existence and multiplicity results of positive solutions are obtained.
Jiqiang Jiang, Lishan Liu, Yonghong Wu
doaj   +1 more source

Existence and uniqueness of positive solutions for fractional differential equations

Boundary Value Problems, 2019
By some new integral inequalities of Henry–Gronwall type, we investigate the existence and uniqueness of positive solutions for fractional differential equations.
Tao Zhu
doaj   +1 more source