Results 61 to 70 of about 214,966 (272)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Some inequalities for the Tutte polynomial
, 2011 This is the post-print version of the Article. The official published version can be accessed from the link below - Copyright @ 2011 ElsevierWe prove that the Tutte polynomial of a coloopless paving matroid is convex along the portion of the line x+y=p ...
Noble, Steven D. +15 more
core +1 more source
Does intellectual property rights protection help reduce carbon emissions?
Humanities & Social Sciences CommunicationsOur study examines the relationship between intellectual property rights protection (IPRP) and carbon emissions (CE) using an unbalanced panel data set from 116 countries spanning 2008–2020.
Pengfei Cheng, Yuhao Wang, Mengzhen Wang
doaj +1 more source
Analysis of public debt trends and poverty reduction in Malawi
Cogent Economics & FinanceHow are poverty and debt related in the short run and long run in the context of a developing economy, such as Malawi? The novelty of the study is that it uses a unique data set spanning from 1983 to 2021 to examine the relationship between poverty and ...
Freeman Munisi Mateko +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
, 2020 Nature’s Net Positive is a community housing project that focuses on using light at three different scales to help achieve its goals. The first scale is site with a focus on a checkerboard pattern of light and dark spaces that interact with nature and ...
Schmoll, Christian
core
Spanning trees and spanning closed walks with small degrees
, 2022 Let $G$ be a graph and let $f$ be a positive integer-valued function on $V(G)$. In this paper, we show that if for all $S\subseteq V(G)$, $\omega(G\setminus S)
Hasanvand, Morteza
core
Graphs admitting antimagic labeling for arbitrary sets of positive numbers [PDF]
, 2020 Hartsfield and Ringel in 1990 conjectured that any connected graph with q >= 2 edges has an edge labeling f with labels in the set {1,..., q}, such that for every two distinct vertices u and v, f(u) not equal= f(v), where f(v) = Sigma(e is an element of ...
Matamala Vásquez, Martín +1 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Improving minimum cost spanning trees by upgrading nodes [PDF]
, 1998 We study budget constrained network upgrading problems. We are given an undirected edge weighted graph ¦¨§ © where node can be upgraded at a cost of © . This upgrade reduces the weight of each edge incident on . The goal is to find
R. Ravi +20 more
core +1 more source