Results 71 to 80 of about 214,966 (272)

Event-Based Clustering Architecture for Power Efficiency in Wireless Sensor Networks

International Journal of Distributed Sensor Networks, 2014
In order to set up WSN in various rigorous environments, the size and power constraints are stricter due to the high demands for convenience and reliability. Therefore, power efficiency is very important for a WSN.
Kai-Ting Yang, Wei Kuang Lai, Shu-Min Li, Yuh-Chung Lin   +3 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

A Matter of Degree: Improved Approximation Algorithms for Degree-Bounded Minimum Spanning Trees

, 2002
In this paper, we present a new bicriteria approximation algorithm for the degreebounded minimum spanning tree problem. In this problem, we are given an undirected graph, a nonnegative cost function on the edges, and a positive integer B∗, and the goal ...
J. Könemann (5455844), Ramamoorthi Ravi (3892354)   +1 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Multi-label Learning Through Minimum Spanning Tree-Based Subset Selection and Feature Extraction

, 2017
Extracting an effective feature set on the basis of dataset characteristics can be a useful proposition to address a classification task. For multi-label datasets, the positive and negative class memberships for the instance set vary from label to label.
C. A. Murthy, Sadhukhan, Payel, Murthy, C. A., Payel Sadhukhan   +3 more
core   +1 more source

Socio-ecological factors of health literacy and physical activity among middle-aged and older Chinese adults

Frontiers in Public Health
BackgroundIn rapidly aging China, physical activity (PA) and health literacy (HL) are increasingly recognized as important components of healthy aging.MethodsA cross-sectional online survey was conducted among Chinese adults aged ≥40 years between July ...
Li Huang, Yanxia Zhao, Haodong Tian, Haowei Liu, Yunfei Tao, Yuping Zhu, Mingyue Yin, Xing Zhang, Hansen Li   +8 more
doaj   +1 more source

Mid-life predictors of late-life depressive symptoms; determining risk factors spanning two decades in the Women’s Heathy Ageing Project

Women's Midlife Health, 2020
Background Data available from longitudinal studies of adequate duration to explore midlife risk factors for late life higher depressive symptom scores in women is lacking.
Katherine E. Campbell, Alexandra Gorelik, Cassandra E. Szoeke, Lorraine Dennerstein   +3 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Geographical versus Industrial Diversification: A Mean Variance Spanning Approach [PDF]

This paper addresses whether country allocation provides benefits over industry allocation in a sample of European country and industry indexes. Strategy performance is compared using a mean-variance spanning test.
Paul EHLING, Sofia B. RAMOS
core