Results 91 to 100 of about 18,081 (306)

Incremental positivity non-preservation by stability multipliers

M G Safonov
exaly   +4 more sources

Positivity violations of the density operator in the Caldeira-Leggett master equation

, 2019
The Caldeira-Leggett master equation as an example of Markovian master equation without Lindblad form is investigated for mathematical consistency. We explore situations both analytically and numerically where the positivity violations of the density ...
József Zsolt Bernád, László Lisztes, Homa, G., Bernad, J. Z., Gábor Homa, Lisztes, László   +5 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Solitary fibrous tumor of the sublingual gland: a case report

Frontiers in Oral Health
ObjectivesTo emphasize the importance of considering solitary fibrous tumor (SFT) in the differential diagnosis of sublingual gland masses, particularly those presenting with unusual symptoms like tongue deviation.MethodsA case of a 41-year-old female ...
Jinpeng Liu, Jinpeng Liu, Yao Yu, Yao Yu, Dongliang Lin, Yaoxiang Xu, Yaoxiang Xu, Yaoxiang Xu, Lei Ma, Lei Ma, Lei Ma   +10 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Perioperative safety evaluation of intersphincteric resection combined with rectal eversion and total extra-abdominal resection: a prospective randomized controlled trial

World Journal of Surgical Oncology
Background Colorectal cancer remains a significant global health burden, with low rectal tumors posing unique surgical challenges due to their proximity to the anal verge.
Zhanpeng Yang, Aizhen Wang, Hong Liang, Qingwen Fan, Shuaipeng Li, Fuqiang Yao, Mengzhe Li, Xi Wang, Chao Zhang   +8 more
doaj   +1 more source

Enteroparasites in Riverside Settlements in the Pantanal Wetlands Ecosystem

Journal of Parasitology Research, 2018
Background. Intestinal parasites are a major source of health problems in developing countries, where socioeconomic, cultural, and environmental conditions contribute in maintaining the biological cycles of various parasites and facilitating their spread.
Patrícia Vieira da Silva, Lucimare dos Santos Maciel, Ludiele Souza Castro, Paula Guerra Murat, Minoru German Higa Junior, Patrícia Honorato Zerlotti, Ana Rita Coimbra Motta-Castro, Elenir Rose Jardim Cury Pontes, Maria Elizabeth Cavalheiros Dorval   +8 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source