Results 71 to 80 of about 18,081 (306)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Immunoexpression of proliferating cell nuclear antigen (PCNA) in spleen of splenectomized rats with preservation of inferior pole, submitted to hyperbaric oxygenation [PDF]

Acta Cirúrgica Brasileira, 2013
PURPOSE: To analyze PCNA immunoexpression on the inferior pole of the spleen of splenectomized rats submitted to hyperbaric oxygenation (HBO). METHODS: Were analyzed fragments of the inferior pole of the spleen of 20 male Wistar rats submitted to ...
Marcela Souza Lima Paulo, Filipy Taifson Barbosa dos Santos, Polyanna Gonçalves Rocha, Mirella de Barros Silva, Luiz Cálice Cintra, Luciene Lage da Motta, Flávia Imbroisi Valle Errera, Danilo Nagib Salomão Paulo, Tarcizo Afonso Nunes   +8 more
doaj   +1 more source

Age differences in conscious versus subconscious social perception: The influence of face age and valence on gaze following. [PDF]

, 2014
Gaze following is the primary means of establishing joint attention with others and is subject to age-related decline. In addition, young but not older adults experience an own-age bias in gaze following.
Ruffman, T, Slessor, Gillian, Bailey, P.E., Ruffman, Ted, Bennetts, Rachel, Bailey, PE, Campbell, Anna, Slessor, G., Bailey, Phoebe E. (R16684), Campbell, A., Rendell, P.G., Ruffman, T., Rendell, PG, Bennetts, Rachel J., Slessor, G, Campbell, A, Rendell, Peter G., Bennetts, RJ   +17 more
core   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

On the completely positive and positive-semidefinite-preserving cones

Linear Algebra and its Applications, 1984
Let \(M_ n\), \(H_ n\), and \(P_ n\) be respectively the complex space of \(n\times n\) complex matrices, the real space of Hermitian matrices in \(M_ n\), and the cone of positive semidefinite matrices in \(H_ n\). The authors show that the cone \(CP_{n,q}\) of completely positive linear maps from \(M_ n\) to \(M_ q\) is isometrically isomorphic to ...
Barker, George Phillip, Hill, Richard D., Haertel, Raymond D.   +2 more
openaire   +2 more sources

Quantitative type theorems in the space of locally integrable functions

, 2022
In this work, we introduce a new modulus of continuity for locally integrable function spaces which is influenced by the natural structure of the L-p space.
Özsaraç, Fırat, Yilmaz, Basar, Aral, Ali   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Comparison of pathogen detection performance between metagenomic next-generation sequencing and conventional culture in organ preservation fluids and recipient wound drainage fluids

Frontiers in Cellular and Infection Microbiology
BackgroundPrompt identification and management of donor-derived infections post-kidney transplantation are critical. This study aims to assess the effectiveness of metagenomic next-generation sequencing (mNGS) in detecting pathogens within donor organ ...
Jiyuan Li, Wenjia Yuan, Chen Gao, Lei Liu, Lei Song, Wei Cao, Xuejing Zhu, Yachun Han, Ruobing Liang, Gongbin Lan, Shaojie Yu, Yu Wang, Liang Tan, Helong Dai, Xubiao Xie, Longkai Peng, Fenghua Peng   +16 more
doaj   +1 more source

Positivity Preservation in the Simulation of Relativistic Laser-Plasma Interaction

, 2013
With standard schemes, the plasma density in the hydrodynamic model for relativistic laser-plasma interaction can become negative. Therefore, we present a new scheme that preserves the positivity of the plasma density while still satisfying the ...
Wortmann, Anke
core   +1 more source