Results 121 to 130 of about 18,081 (306)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Preservation of certain dependent structures under bivariate homogeneous Poisson shock models

, 1997
A bivariate Poisson shock model resulting from two devices receiving shocks from two independent sources is shown to preserve certain bivariate dependent structures such as total positivity of order 2 (TP2), stochastic increasing (SI), right tail ...
SABNIS, SV, BALU, MN
core   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Preserving positive polynomials and beyond

, 2008
Following the classical approach of Pólya-Schur theory we initiate in this paper the study of linear operators acting on $\mathbb{R}[x]$ and preserving either the set of positive univariate polynomials or similar sets of non-negative and elliptic polynomials.
Borcea, Julius, Guterman, Alexander, Shapiro, Boris   +2 more
openaire   +2 more sources

Computational investigation of tuberculosis and HIV/AIDS co-infection in fuzzy environment

Nonlinear Engineering
Tuberculosis (TB) and human immunodeficiency virus (HIV)/acquired immunodeficiency virus (AIDS) have a fatal bidirectional connection with a significant global epidemic overlap.
Kaushik Harshita, Verma Vijai Shanker, Singh Ram, Jain Sonal, Boulaaras Salah   +4 more
doaj   +1 more source

Maxillary Ewing Sarcoma in a Teenager: A Case Report

Case Reports in Oncology
Introduction: Ewing sarcoma (ES) is an aggressive primary bone cancer, primarily affecting children and adolescents, accounting for 5% of cancers in this demographic. ES most commonly affects males during adolescence. It primarily targets flat
Ahmad Al-Bitar, Mahdi Sandouk
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Rapid Antigen Detection Testing as Supportive Tool in Group A Streptococcal Necrotizing Soft Tissue Infection Management: A Case Series

Acute Medicine & Surgery
Background Necrotizing soft tissue infection caused by Group A β‐hemolytic Streptococcus (GAS) requires early recognition and intervention due to its rapid progression and high mortality. While rapid antigen detection testing (RADT) is primarily designed
Yutaka Enomoto, Yoshihiro Aoki, Rina Akashi, Kentaro Yoshino, Kohei Kuga, Atsuko Tachikawa, Daisuke Sugawara, Tomoko Hiraoka, Kensuke Takahashi, Shuhei Yamano, Motoi Nakano, Koichi Hayakawa, Osamu Tasaki   +12 more
doaj   +1 more source

Conservation of Mass and Preservation of Positivity with Ensemble-Type Kalman Filter Algorithms

, 2013
This paper considers the incorporation of constraints to enforce physically based conservation laws in the ensemble Kalman filter. In particular, constraints are used to ensure that the ensemble members and the ensemble mean conserve mass and remain ...
Verlaan, Martin, Janjic, Tijana, Cohn, Stephen E., Mclaughlin, Dennis   +3 more
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source