Results 141 to 150 of about 7,957,612 (305)

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Recovering Complete Positivity of Non-Markovian Quantum Dynamics with Choi-Proximity Regularization

Physical Review X
A relevant problem in the theory of open quantum systems is the lack of complete positivity of dynamical maps obtained after weak-coupling approximations, a famous example being the Redfield master equation.
Antonio D’Abbruzzo, Donato Farina, Vittorio Giovannetti   +2 more
doaj   +1 more source

A dynamically consistent and time-efficient numerical design for the reaction diffusion model in three space dimensions

Applied Mathematics in Science and Engineering
In this study, a famous Brusselator non-linear model arising in enzymatic and triple collision is considered to analyse its various physical features. These features include positivity, stability, and convergence.
Nauman Ahmed, Muhammad Rafiq, Muhammad Aziz-ur Rehman, Tahira Sumbal Shaikh, Aisha M. Alqahtani, Ilyas Khan, Muhammad Imran, Shafiullah Niazai   +7 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Positive Linear Operators Preserving ? and ?2

, 2019
In the paper we introduce a general class of linear positive approximation processes defined on bounded and unbounded intervals designed using an appropriate function. Voronovskaya type theorems are given for these new constructions. Some examples including well known operators are presented. © 2019 Selcuk University. All Rights Reserved.
ACAR, TUNCER, ARAL, ALI, RAŞA, IOAN
openaire   +2 more sources

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Strict positivity and explicit integral representation of Green’s function for high-order clamped boundary value problems

Boundary Value Problems
The operator ( − 1 ) M ( d / d x ) 2 M $(-1)^{M} (d/dx)^{2M}$ , with the factor ( − 1 ) M $(-1)^{M}$ chosen to ensure the positivity of associated Green’s function, plays a central role in the formulation.
Kazuo Takemura, Atsushi Nagai, Hiroto Sekido   +2 more
doaj   +1 more source