Results 41 to 50 of about 216,080 (283)

Cortical Activity During an Attack of Ménière's Disease—A Case Report

Frontiers in Neurology, 2021
Background: Ménière's disease (MD) is a chronic peripheral vestibular disorder with recurrent episodes of vertigo accompanied by fluctuating hearing loss, tinnitus and aural fullness in the affected ear. There are several unanswered fundamental questions
Louise Devantier, Louise Devantier, Allan K. Hansen, Jens-Jacob Mølby-Henriksen, Michael Pedersen, Michael Pedersen, Per Borghammer, Therese Ovesen, Therese Ovesen, Måns Magnusson   +9 more
doaj   +1 more source

Development of an automated method for in-house production of sodium 18F-fluoride for injection: process validation as a step toward routine clinical application

EJNMMI Radiopharmacy and Chemistry
Background Sodium 18F-fluoride for injection can be easily cyclotron-produced and purified, as a simple inorganic salt, by adsorption/desorption onto an anion-exchange cartridge and then dispensed for clinical use.
Marija Atanasova Lazareva, Maja Chochevska, Katerina Kolevska, Maja Velickovska, Filip Jolevski, Paulina Apostolova, Ana Ugrinska, Emilija Janevik-Ivanovska   +7 more
doaj   +1 more source

A DNA-damage immune response assay combined with PET biomarkers predicts response to neo-adjuvant chemotherapy and survival in oesophageal adenocarcinoma

Scientific Reports, 2021
18F-fluorodeoxyglucose PET-CT may guide treatment decisions in patients with oesophageal adenocarcinoma (OAC). This study evaluated the added value of maximum standardised uptake value (SUVmax) to a novel DNA-damage immune response (DDIR) assay to ...
Kieran G. Foley, Anita Lavery, Eoin Napier, David Campbell, Martin M. Eatock, Richard D. Kennedy, Kevin M. Bradley, Richard C. Turkington   +7 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Integrative systems‐level analysis reveals a contextual crosstalk between hypoxia and global metabolism in human breast tumors

Molecular Oncology, EarlyView.
Breast tumor samples scored for metabolic deregulation (M1 to M3) were given a hypoxia score (HS). The highest HS occurred in patients with strongest metabolic deregulation (M3), supporting tumor aggressiveness. HS correlated with the highest number of metabolic pathways in M1. This suggests hypoxia to be an early event in metabolic deregulation.
Raefa Abou Khouzam, Salem Chouaib, Mohammad Askandar Iqbal   +2 more
wiley   +1 more source

Reduced Expression of Cerebral Metabotropic Glutamate Receptor Subtype 5 in Men with Fragile X Syndrome

Brain Sciences, 2020
Glutamatergic receptor expression is mostly unknown in adults with fragile X syndrome (FXS). Favorable behavioral effects of negative allosteric modulators (NAMs) of the metabotropic glutamate receptor subtype 5 (mGluR5) in fmr1 knockout (KO) mouse ...
James R. Brašić, Ayon Nandi, David S. Russell, Danna Jennings, Olivier Barret, Anil Mathur, Keith Slifer, Thomas Sedlak, Samuel D. Martin, Zabecca Brinson, Pankhuri Vyas, John P. Seibyl, Elizabeth M. Berry-Kravis, Dean F. Wong, Dejan B. Budimirovic   +14 more
doaj   +1 more source

Pre-Operative Prediction of Mediastinal Node Metastasis Using Radiomics Model Based on 18F-FDG PET/CT of the Primary Tumor in Non-Small Cell Lung Cancer Patients

Frontiers in Medicine, 2021
Purpose: We investigated whether a fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography (18F-FDG PET/CT)-based radiomics model (RM) could predict the pathological mediastinal lymph node staging (pN staging) in patients with ...
Kai Zheng, Kai Zheng, Kai Zheng, Xinrong Wang, Chengzhi Jiang, Yongxiang Tang, Zhihui Fang, Jiale Hou, Zehua Zhu, Shuo Hu, Shuo Hu, Shuo Hu   +11 more
doaj   +1 more source

Cardiac Positron Emission Tomography

Journal of the American College of Cardiology, 2009
Positron emission tomography (PET) is a powerful, quantitative imaging modality that has been used for decades to noninvasively investigate cardiovascular biology and physiology. Due to limited availability, methodologic complexity, and high costs, it has long been seen as a research tool and as a reference method for validation of other diagnostic ...
Frank M. Bengel, Riikka Lautamäki, Takahiro Higuchi, Mehrbod S. Javadi   +3 more
openaire   +3 more sources

Diagnostic image‐based treatment planning for online adaptive ultra‐hypofractionated prostate cancer radiotherapy with MR‐Linac

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose A new workflow was investigated for Elekta Unity MR‐Linac by removing the computed tomography (CT)‐simulation step and using diagnostic CT (DCT) for reference plan generation. Materials and methods Ten patients with ultra‐hypofractionated prostate cancer treated with magnetic resonance imaging (MRI)‐guided adaptive radiotherapy were ...
Yuan Xu, Ningning Lu, Qiao Li, Kuo Men, Xinming Zhao, Jianrong Dai   +5 more
wiley   +1 more source

Shielding resources for four common radiopharmaceuticals utilized for imaging and therapy: Tc‐99m, F‐18, I‐131, and Lu‐177

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction The use of radioactive materials in the United States has been tightly regulated by the Nuclear Regulatory Commission and other entities for many decades. In 2015, however, the Joint Commission began to require hospital‐based nuclear medicine departments to conduct shielding designs and evaluations for radioactive material areas ...
Michael Oumano, Richard Wendt, James Botti, Nathan Busse, David Hintenlang, Stephanie Leon, Kevin Little, Melissa Martin, Richard Massoth, Kenneth Matthews, Rameshwar Prasad, Sharon White, Jessica Clements   +12 more
wiley   +1 more source