Results 131 to 140 of about 1,912,136 (307)

Comparison of magnetic resonance imaging-fluorodeoxyglucose positron emission tomography fusion with pathological staging in rectal cancer

, 2009
Background: This study represents an initial experience with combined magnetic resonance imaging (MRI) and [(18)F]fluorodeoxyglucose positron emission tomography (FDG PET) (MRI-PET fusion) in the primary staging of rectal ...
Stevenson, A. R. L., Lai, J., Kam, M. H., Siu, S., Phillips, G. E., Wong, D. C., D C Wong, S Siu, G E Phillips, J Lai, M H Kam, A R L Stevenson   +11 more
core   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Positron Emission Tomography and Computer Tomography (PET/CT) in Prostate, Bladder, and Testicular Cancers

, 2010
Positron emission computed tomography (PET) is a functional, noninvasive method for imaging regional metabolic processes that is nowadays most often combined to morphological imaging with computed tomography (CT).
Mirimanoff, R.O., Prior, J.O., Meuwly, J.Y., R.-O. Mirimanoff, Delaloye, A.B., P. Jichlinski, M. Schaffer, J.-Y. Meuwly, Zouhair, A., A. Bischof Delaloye, S. Albrecht, Albrecht, S., M. Ozsahin, Ozsahin, M., J.O. Prior, Jichlinski, P., Camus, F., A. Zouhair, F. Camus, Schaffer, M., Mirimanoff RO, Albrecht S, Ozsahin M, Camus F, Jichlinski P, Prior JO, Schaffer M, Zouhair A, Bischof Delaloye A, Meuwly JY   +29 more
core   +1 more source

Expert Perspectives: Defining and Managing Progressive Pulmonary Fibrosis in Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Systemic sclerosis–associated interstitial lung disease (SSc‐ILD) is one of the leading causes of morbidity and mortality in SSc, affecting up to three‐quarters of patients. The disease course is highly heterogeneous, ranging from indolent, nonprogressive forms to rapidly progressive pulmonary fibrosis (PPF).
Devis Benfaremo, Dinesh Khanna, Corrado Campochiaro, Vincent Cottin, Fabrizio Luppi, Marco Matucci‐Cerinic, Gianluca Moroncini, Yannick Allanore   +7 more
wiley   +1 more source

Staging, treatment and prognosis: is 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) a possible link of union?

, 2012
Staging, treatment and prognosis: is 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) a possible link of ...
Anna Rita Cervino, Laura Evangelista, Vanna Chiarion Sileni, Silvia Stragliotto, Carlo Castoro, Sara Galuppo, POMERRI, FABIO, Rita Alfieri, MUZZIO, PIER CARLO   +8 more
core  

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Mathematical modelling and identifiability applied to positron emission tomography data [PDF]

Positron emission tomography (PET) is an in vivo tracer kinetic technique. This thesis is concerned with the analysis of data derived from PET studies in humans. There are two related themes in the thesis.
Gunn, Roger
core  

The integrated Lei‐CNS PBPK‐PD model effectively predicts clozapine brain disposition and D2 receptor occupancy in humans

British Journal of Clinical Pharmacology, EarlyView.
Aim Clozapine, used for treatment‐resistant schizophrenia, has a narrow therapeutic window and highly variable plasma pharmacokinetics (PK), necessitating careful monitoring. Direct measurement of unbound brain PK in humans is unethical. To develop a physiologically based pharmacokinetic–pharmacodynamic (PBPK‐PD) model to predict clozapine brain ...
Mengxu Zhang, Thomas I. F. H. Cremers, Vivi Rottschäfer, Elizabeth C. M. de Lange   +3 more
wiley   +1 more source

Accelerating green heterocyclic synthesis: Convergence of AI, automation, and sustainable chemistry

Bulletin of the Korean Chemical Society, EarlyView.
Green heterocyclic synthesis and data‐driven tools such as AI, high‐throughput experimentation, continuous flow, and self‐driving laboratories have developed largely in parallel. This review connects them and asks how green metrics such as E‐factor and PMI might serve as explicit optimization targets rather than post‐hoc measures, toward sustainable ...
Noor Aisyah Ahmad Shah, Amirreza Mottafegh, Su‐Hyun Yoo, Jongwoon Kim, Minseon Byeon, Juhwan Noh, Yea‐Lee Lee, Jin Suk Myung, Gwang‐Noh Ahn   +8 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source