Results 131 to 140 of about 494,691 (265)

Clinical Benefit of Pembrolizumab in Lynch Syndrome‐Associated Advanced Ovarian Cancer With Germline MSH6 Variant: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT This case highlights the importance of genetic evaluation during treatment in young patients with advanced ovarian cancer. Lynch syndrome caused by a germline MSH6 pathogenic variant was diagnosed during first‐line maintenance therapy, and pembrolizumab achieved a durable response in recurrent disease.
Tomomi Yokozawa, Sayako Nakagawa, Yukio Suzuki, Aya Tokinaga‐Uchiyama, Katsuyuki Konnai, Hiroto Narimatsu, Yukihiko Hiroshima, Haruya Saji   +7 more
wiley   +1 more source

Recent Advancements in Drug Delivery Across the Blood–Brain Barrier in Amyotrophic Lateral Sclerosis (ALS)

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai, Kaitlyn Pierce, Nidhi Sharma, Sasha Leggett, Tara Chand Yadav, Pegah Masrori, Devi Atukorallaya, Senthilnathan Palaniyandi, Paul C. Marcogliese, Geoffrey K. Tranmer   +9 more
wiley   +1 more source

Left Cerebellar‐Right Frontal Uncoupling in Female First‐Episode Major Depressive Disorder: Synaptic Evidence From [18F]UCB‐H PET

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
This study investigates cerebello‐cerebral synaptic function in female first‐episode major depressive disorder (FMD) using [18F]UCB‐H PET imaging. Compared to healthy controls (HCs), FMD patients show reduced SUVR in the left cerebellar lobule VII and synaptic tracer uptake in the left cerebellar lobule VIII, which correlates negatively with depression
Juehan Wang, Yajun Lin, Tianfang Zhang, Pengfeng Xu, Shanyan Lei, Hong Yang, Zuobing Chen   +6 more
wiley   +1 more source

Rational design of Ni‐based catalysts for methane dry reforming: Recent advances and future perspectives

FlexMat, Volume 3, Issue 3, Page 428-451, September 2026.
Addressing the challenges inherent in dry reforming of methane (DRM), this paper focuses on the structural design and performance optimization of Ni‐based catalysts. The modulation strategies for DRM are systematically reviewed across four dimensions: the micromorphology of active metals, metal‐support interactions, electronic modifications by ...
Bowei Cao, Junlei Zhang, Wanglei Wang
wiley   +1 more source

Investigating the Contribution of Molecular‐Enriched Functional Connectivity to Brain‐Age Analysis

Human Brain Mapping, Volume 47, Issue 13, September 2026.
ABSTRACT Brain‐age prediction from neuroimaging data provides a proxy of biological aging, yet most models rely on structural magnetic resonance imaging (MRI), a modality that captures macroanatomy but offers limited biological specificity. We tested whether integrating molecular‐enriched functional connectivity (FC) from resting‐state functional MRI ...
Marco Pinamonti, Manuela Moretto, Valentina Sammassimo, Marco Castellaro, Mattia Veronese   +4 more
wiley   +1 more source

Correlation between positron annihilation lifetime and photoluminescence measurements for calcined Hydroxyapatite

Scientific Reports
Hydroxyapatite (HAp) Ca10(PO4)6(OH)2 is a compound that has stable chemical properties, composition, and an affinity for human bone. As a result, it can be used in odontology, cancer treatment, and orthopedic grafts to repair damaged bone.
Hoda Atta, Kamal R. Mahmoud, Elsayed I. Salim, Eithar Elmohsnawy, Abdelhamid El-Shaer   +4 more
doaj   +1 more source

Positron Lifetime Calculation for Defects in Graphite

Positron lifetime calculation has been performed for a vacancy and vacancy clusters in graphite and the comparison with experimental result was also made.
Onitsuka, Takashi, Tsukuda, Noboru, Kuramoro, Eiichi, クラモト, エイイチ, 大窪, 秀明, 鬼塚, 貴志, オニツカ, タカシ, 蔵元, 英一, オオクボ, ヒデアキ, ツクダ, ノボル, Ohkubo, Hideaki, タケナカ, ミノル, 佃, 昇, Takenaka, Minoru, 竹中, 稔   +14 more
core  

EEG Biomarkers for Affective Disorders Diagnosis: An Evaluation and Validation Study

Human Brain Mapping, Volume 47, Issue 13, September 2026.
In this review, we introduce 25 EEG biomarkers for affective disorders diagnosis. We then validate their predictive ability across a public EEG dataset composed of healthy controls and subjects with different affective disorders, and provide a comprehensive analysis and discussion.
Sha Zhao, Yitian Liu, Jiquan Wang, Ruizhe Zhang, Yilin Wang, Haiteng Jiang, Shijian Li, Tao Li, Gang Pan   +8 more
wiley   +1 more source

Fibroblast Activation Protein Expression Differs Between Inflamed and Fibrostenotic Inflammatory Bowel Disease

JCC Plus, Volume 1, Issue 5, September 2026.
This study demonstrates that fibroblast activation protein expression is elevated in inflamed and fibrostenotic inflammatory bowel disease, with highest levels in fibrostenotic Crohn's disease. Cellular fibroblast activation protein predominates in inflamed tissues and localises to α‐SMA−PDPN−CD90+ stromal cells. ABSTRACT Background Intestinal fibrosis
Dalia A. Lartey, Bram W. van Os, Bo Jun Ke, Kelly van Wijnbergen, Gert de Hertogh, Luuk J. A. C. Hawinkels, Gianluca Matteoli, Jie Su, Christianne J. Buskens, Jarmilla D. W. van der Bilt, Geert R. A. M. D'Haens, Joep Grootjans, Manon E. Wildenberg, Marieke C. Barnhoorn, Mark Löwenberg   +14 more
wiley   +1 more source

Cell Death in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Regulated cell death pathways, including apoptosis, necroptosis, pyroptosis, ferroptosis, and autophagy‐dependent cell death, interact with mitochondrial dysfunction, proteostasis failure, lysosomal stress, glial remodeling, and neuroinflammation across major neurodegenerative diseases.
Tianjiao Li, Qian Zhang, Yichen Wu, Ruixue Huang   +3 more
wiley   +1 more source