Results 101 to 110 of about 151,758 (309)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Remarks on the syntax of the „Kvaderna kapitula lovranskoga“

open access: yesZbornik Lovranšćine, 2014
The paper, based on the transliteration edition of Damir Viškanić, analyzes and describes selected and previously unexplored syntactic topics of the Chakavian-glagolitic part of the Kvaderna kapitula lovranskoga.
Ana Kovačević, Lucija Turkalj
doaj  

Situer la possession. Du droit romain de l’appartenance aux nouveaux modèles propriétaires

open access: yesClio@Themis, 2018
This article calls for a reengagement with historical forms of legal appropriation. Exploring ways to benefit from a ressource that ran parallel to exclusive property, it aims at providing legal scholars with an archeological touchstone capable of ...
Pierre Thévenin
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

Relax laws on possession of drugs, urges Dáil committee.

open access: yes, 2015
The Oireachtas Justice Committee is preparing to recommend the Government decriminalise the possession of small amounts of all drugs in a bid to alleviate pressure on garda resources and the courts from low level crime.....
Ryan, Philip
core  

Critical legal geographies of possession : Antarctica and the International Geophysical Year 1957–1958

open access: yes, 2010
This is an article about the politics of territory in Antarctica. It revolves around what at first seems like a very\ud simple geopolitical question: who owns Antarctica? As this article demonstrates, this seemingly simple\ud question is far from easy to
Collis, Christy
core   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

open access: yesFEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe   +5 more
wiley   +1 more source

Romance forms in A. S. Byatt\u27s Possession

open access: yes, 1995
A. S. Byatt\u27s Possession: A Romance (1990) is best defined as a quest narrative, as it follows the pattern that Campbell, Propp and Frye among others have described.
Cuder Domínguez, Pilar
core  

Possession or position games: What is the key in soccer?

open access: yes
The aims of this study were to compare the running performance of possession and position games and to describe the external load of the same position game played on pitches of different dimensions.
Borja Muñoz   +3 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

open access: yesFEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake   +4 more
wiley   +1 more source

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