Results 121 to 130 of about 1,081,743 (292)

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

open access: yesFEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul   +3 more
wiley   +1 more source

Molecular determinants of signal transduction in tropomyosin receptor kinases

open access: yesFEBS Open Bio, EarlyView.
Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

open access: yesFEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner   +6 more
wiley   +1 more source

SHARIAH ISSUES OF OWNERSHIP AND POSSESSION OF ASSET-BASED SUKUK STRUCTURE: A SHARIAH SCHOLARS’ PERSPECTIVE

open access: yesUUM Journal of Legal Studies
Sukuk serves as an instrument in the global Islamic financial market, which has experienced expansion in recent years. Despite this notable growth, Sukuk encounters Shariah-related concerns pertaining to the possession of underlying assets.
Ibraheem Alani AbdulKareem   +1 more
doaj   +1 more source

Calcium‐sensing receptor induces the apoptosis of chondrocytes in cooperation with phosphate transporter

open access: yesFEBS Open Bio, EarlyView.
Excess Ca2+ ions activate the Calcium‐Sensing Receptor (CaSR), which subsequently drives the uptake of excess inorganic phosphate (Pi) via the Pi transporter (Pit−1) in chondrocytes. This mechanism causes a toxic increase in intracellular Pi concentration, ultimately leading to chondrocyte apoptosis and pathological mineralization. Excess extracellular
Sachie Nakatani   +7 more
wiley   +1 more source

How to possess an electronic bill of lading as information? A comparative perspective of the legislation on the “possession problem” of electronic bills of lading

open access: yesFrontiers in Marine Science
The possession of the paper B/Ls is the basis of the function of a B/L as a document of title in common law systems and the delivery effect of B/Ls in civil law systems. The “possession problem” of eB/Ls is how to ensure that eB/Ls, as intangible objects,
Siqi Sun, Ran He
doaj   +1 more source

The effect of the maintaining the ball possession on the intensity of games [PDF]

open access: gold, 2016
Felipe Lovaglio Belozo   +8 more
openalex   +1 more source

Drugs research: an overview of evidence and questions for policy [PDF]

open access: yes, 2010
In 2001 the Joseph Rowntree Foundation embarked upon a programme of research that explored the problem of illicit drugs in the UK. The research addressed many questions that were often too sensitive for the government to tackle.
Lloyd, C., McKeganey, N.
core  

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