Results 41 to 50 of about 84,381 (266)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

open access: yesFEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Control over the Human Body Before and After Death: The Civil Law Aspect

open access: yesBRICS Law Journal, 2020
In this article, an attempt is made to determine the legal status of the human body (organs and tissue) both while a person is alive and after a person dies.
L. Novoselova
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Penser la physique du pouvoir. La possession de la juridiction dans les commentaires d’Innocent IV et d’Antonio de Budrio à la décrétale Dilectus

open access: yesClio@Themis, 2016
Dated 1201, the Dilectus decretal of Innocent III is included into the 3 Compilatio (3.29.c.un.) and the Liber Extra (3.37.2). Since Innocent IV’s comment (ca. 1245), it became a reference value for the theme of possession of jurisdiction.
Marta Madero
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

SOME CONSIDERATIONS REGARDING THE DELIVERY METHODS OF LEGATES IN ROMANIAN LEGISLATION [PDF]

open access: yesChallenges of the Knowledge Society, 2014
Legacies have an important influence in the Romanian law, respectively in the succession law. So that the legate was defined as the legal act encompassed in a testament by which the testator shall designate one or more persons who, at his death, will ...
Ana-Maria GHERGHINA (VASILE)
doaj  

The human gut microbiome across the life course

open access: yesFEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero   +4 more
wiley   +1 more source

Locatio in Roman agrimensura

open access: yesRUDN Journal of World History
The relevance of this study is due to the lack of works in Russian historiography that would examine in detail the phenomenon of locatio as an act of creating a possession.
Inna A. Gvozdeva
doaj   +1 more source

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