Results 61 to 70 of about 84,381 (266)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Rudolph Sohm and his influences on the definition of the law of property in The Middle Ages. A reinterpretation of ownership in Transylvania(1308-1342)

Vergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2018
This article addresses firstly the terminological problems modern historian sencounter when discussing the law of property in the Middle Ages, and how its decontextualization has led to numerous inaccurate studies in the field of legal history, and ...
Mihai Safta
doaj  

The Soteriological Context of a Tibetan Oracle

HIMALAYA, 2019
This paper contributes to the study of Tibetan oracles by analyzing a distinctive case of a contemporary Tibetan oracle living in exile in India. The oracular practice and personal history of Lhamo, or ‘Goddess,’ present several unusual features compared
Katarina Turpeinen
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Kamala Markandaya's A Silence of Desire and Possession (Exploring Psychological Dimensions of Spirituality)

Rhesis, 2010
Kamala Markandaya belonged to that pioneering group of Indian women writers who made their mark not just through their subject matter, but also through their fluid, polished fictional technique.
Naveen K. Metha
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Personality Separation Anxiety Problem in the Method «I-Reconstruction»

Вісник Харківського національного університету імені В.Н. Каразіна. Серія: Психологія
The article deals with the adult separation anxiety problem through the psychotherapy method "I-reconstruction". A definition of the separation anxiety concept is given as well as it highlights the process of the anxiety occurrence in psychological ...
Yuliia Zinchenko
doaj   +1 more source

Purpose as a Sign of the Subjective Side of Corpus Delicti Provided By Article 174.1 of the Criminal Code of the Russian Federation

Сибирское юридическое обозрение, 2019
The Author of the article considers the problematic issues of the subjective side of the corpus delicti of the legalization (laundering) of money or other property acquired by a person as a result of his committing a crime under Art.
M. V. Lupyr'
doaj   +1 more source