Results 71 to 80 of about 151,758 (309)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Adverse possession: Moral authority

, 2018
Naveed Ali analyses the evolution of adverse possession ‘Despite this “unjust” method of acquisition, there are numerous arguments in favour of adverse possession.
Ali, Naveed
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Rudolph Sohm and his influences on the definition of the law of property in The Middle Ages. A reinterpretation of ownership in Transylvania(1308-1342)

Vergentis. Revista de Investigación de la Cátedra Internacional Conjunta Inocencio III, 2018
This article addresses firstly the terminological problems modern historian sencounter when discussing the law of property in the Middle Ages, and how its decontextualization has led to numerous inaccurate studies in the field of legal history, and ...
Mihai Safta
doaj  

The Soteriological Context of a Tibetan Oracle

HIMALAYA, 2019
This paper contributes to the study of Tibetan oracles by analyzing a distinctive case of a contemporary Tibetan oracle living in exile in India. The oracular practice and personal history of Lhamo, or ‘Goddess,’ present several unusual features compared
Katarina Turpeinen
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Kamala Markandaya's A Silence of Desire and Possession (Exploring Psychological Dimensions of Spirituality)

Rhesis, 2010
Kamala Markandaya belonged to that pioneering group of Indian women writers who made their mark not just through their subject matter, but also through their fluid, polished fictional technique.
Naveen K. Metha
doaj   +1 more source

Decriminalisation of drug use and possession in Australia – A briefing note.

, 2016
Currently there is debate about how Australia could better respond to illegal drugs and the associated harm. One frequently raised option is “decriminalisation of drug use and possession”.
Barratt, M, Moxham-Hall, V, Hughes, C ; https://orcid.org/, Barratt, M ; https://orcid.org/, Chalmers, J, Ritter, A ; https://orcid.org/, Hughes, C, Ritter, A, Lancaster, K ; https://orcid.org/, Lancaster, K, Moxham-Hall, V ; https://orcid.org/   +10 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Rethinking Demonic Possession: The impact of the debates about the John Darrel case on later demonological thought, with particular reference to John Deacon and John Walker

, 2013
The controversy that led to the conviction of the Puritan exorcist John Darrel for fraud in 1599 has mainly been viewed by historians in the context of the struggle between Puritans and the Church of England.
Bhogal, Harman
core