Results 101 to 110 of about 17,042 (345)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Possessive constructions in Tolai

, 1982
Possessive constructions are grammatical constructions which contain two nominals and express that the referent of one of these nominals belongs to the other. The kind of relationship denoted by possessive constructions is not only that of ownership (1),
Mosel, Ulrike
core  

Predicative possession in Mande languages

Mandenkan
This article discusses the typology of predicative possession in Mande languages and compares the diversity observed in this domain across the Mande language family with that observed elsewhere in the world, in particular in the language families of West
Denis Creissels
doaj   +1 more source

Habeo-Picture of the World in Russkaya Pravda

Вестник Волгоградского государственного университета: Серия 2. Языкознание, 2017
The article examines possessive relations reflected in the text of Russkaya Pravda. It gives a brief outline of the prototypical possessive relations including the subject-possessor, the object of possession and the second participant of the situation ...
Marina V. Milovanova
doaj   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Possessive Attribute im Deutschen [PDF]

, 2016
In diesem Beitrag wird eine neue, funktional motivierte Systematik für den adnominalen Genitiv und entsprechende von-Phrasen, die zusammenfassend als ‘possessive Attribute’ bezeichnet werden, entwickelt.
Zifonun, Gisela
core  

The relationship between (in)alienable possession and the (three potential) forms of possessed nouns in Hungarian

Linguistica, 2016
The paper gives a thorough insight into the system of possible forms of (in)alienably possessed nouns in Hungarian. Its point of departure is the group of [Nominative + -j- +A] possessive forms the stem of which has an alternative (morphologically ...
Judit Farkas, Gábor Alberti
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source