Results 101 to 110 of about 79,780 (296)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

The Study of the Development of Dependent Possessive Pronouns in 2.5-4 Year-Old Typically Normal Persian-Speaking Children

Journal of Rehabilitation Sciences and Research, 2015
Background: Pronoun error is one of the most common errors in many speech and language disorders. Therefore, knowing about the development procedure of dependent possessive pronouns (as a subgroup of pronouns), leads to build an accurate profile for ...
Shoeleh Sharifypour, Talieh Zarifian, Ayoub Sheikhi, Sharifeh Sharifypour   +3 more
doaj  

A Comparative Analysis of the Expression of Possessive Relations in the Erzya Dialects of the Kochkurovo District, Republic of Mordovia

Финно-угорский мир
Introduction. The dialects of the Mordovian Prisurye are characterized by a developed system of possessive suffixes and feature various means and forms of expressing possessive relations.
Ivan N. Ryabov, Nina A. Agafonova, Galina V. Ryabova   +2 more
doaj   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Reference resolution in multi-modal interaction: Preliminary observations [PDF]

, 2002
In this paper we present our research on multimodal interaction in and with virtual environments. The aim of this presentation is to emphasize the necessity to spend more research on reference resolution in multimodal contexts. In multi-modal interaction
Nijholt, A.
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Language typology in the UNITYP model : paper presented for the XIV. International Congress of Linguists, August 1987, Berlin, DDR, Plenary Session on Typology [PDF]

, 1987
The aim of this contribution is to embed the question of an antinomy between "integral" vs. "partial typology", inscribed as the topic of this plenary session, into the comprehensive framework of the dimensional model of the research group on language ...
Seiler, Hansjakob
core  

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

"Ho trakka han på foten" – ein eksoskeletal analyse av possessivt objekt

Maal og Minne
Possessive objekt, som han i ho trakka han på foten, er spesielle av to grunnar: dei kjem ofte i tillegg til verbets konvensjonelle argument­struktur (trakke er eit typisk intransitivt verb, men tar possessivt objekt), og dei blir tolka som eigar av eit ...
Ragnhild Eik
doaj   +1 more source