Results 51 to 60 of about 11,776 (300)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Quand les possessifs ne servent pas à introduire un nouveau référent : analyse de corpus [PDF]
SHS Web of ConferencesThis article presents a corpus study of possessive noun phrases in French. Possessive determiners are usually presented as determiners dedicated to the first mention of referents, which is not always the case. The study presented in this paper shows that
Manuélian Hélène, Delaborde Marine
doaj +1 more source
Whose name is it anyway? Varying patterns of possessive usage in eponymous neurodegenerative diseases [PDF]
PeerJ, 2013 There has been long-standing debate over whether use of the possessive form of the names of eponymous neurological disorders should be abandoned. Which view has actually predominated in practice?
Michael R. MacAskill, Tim J. Anderson
doaj +2 more sources
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
3rd person possessives: Old Portuguese and Modern Brazilian Portuguese
Filologia e Linguística Portuguesa, 2014 This paper addresses some comparative aspects of the 3rd person possessive pronouns seu and dele in Modern Brazilian Portuguese (BP) and Old Portuguese (OP).
Maria Aparecida Torres Morais +1 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Possessive indexes in Assamese [PDF]
, 2019 This paper deals with a comprehensive description of a set of possessive indexes found in Assamese, a language spoken in the eastern part of India, by a majority of people living in the state of Assam.
Bez, Gitanjali
core +1 more source