Results 71 to 80 of about 79,780 (296)
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Observations on non-possessive usages of personal markers (possessive suffixes) in Nganasan
Eesti ja Soome-ugri Keeleteaduse Ajakiri, 2015 This paper aims at a systematic overview of the non-possessive usages of possessive (relational) suffixes in Nganasan. In the analyzed corpus, the non-anchoring usage types of the 3rd person suffix (including the direct anaphoric and situational usages),
Réka Zayzon
doaj +1 more source
Three Algorithms for Competence-Oriented Anaphor Resolution [PDF]
, 2005 In the last decade, much effort went into the design of robust third-person pronominal anaphor resolution algorithms. Typical approaches are reported to achieve an accuracy of 60-85%.
Stuckardt, Roland
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Compound Formation in Karachay-Balkar: Implications for the marker –sI
Dilbilim Araştırmaları Dergisi, 2017 This paper discusses morphological, phonological, semantic and syntactic properties of compound formation in Karachay-Balkar with a special focus on Noun-Noun compounds which surface with or without marker –sI and sheds new light on compound formation in
Aslı Gürer
doaj +1 more source
The copula and existential verbs in Qiang [PDF]
, 2010 This paper discusses the copula and existential verb constructions in Qiang, a Tibeto-Burman language of northern Sichuan ...
Huang, Chenglong, LaPolla, Randy J.
core
A tribute to Elizaveta Ubryatova: professional life and personal destiny [PDF]
, 2015 The article was submitted on 10.06.2015. Translated by Dr. Lilia Gorelova.In Russia, the name of prominent turkologist Elizaveta Ivanovna Ubryatova, at present is known mostly to specialists who study the languages spoken by the Northern peoples of the ...
Shirobokova, N. +1 more
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source