Results 71 to 80 of about 59,256 (283)

Longitudinal Cohort Study Investigating Fall Risk Across Diverse Muscle Health Statuses Among Older People in the Community

Journal of Cachexia, Sarcopenia and Muscle
Background Falls constitute a significant public health concern among older adults, particularly those with diminished muscle health integrity. The relative contributions of reduced muscle mass versus impaired muscle function to fall risk remain debated.
Yuan‐Ping Chao, Wen‐Hui Fang, Tao‐Chun Peng, Li‐Wei Wu, Hui‐Fang Yang, Tung‐Wei Kao   +5 more
doaj   +1 more source

The longitudinal association between possible new sarcopenia and the depression trajectory of individuals and their intimate partners

Frontiers in Aging Neuroscience, 2022
BackgroundIt is currently unknown whether the dynamic nature of depression affects the development of sarcopenia. Herein, this study aims to assess the association between possible new sarcopenia and the depression trajectory of individuals and their ...
Yufeng Tian, Yufeng Tian, Zhigang Hu, Zhigang Hu, Zhigang Hu, Xinyu Song, Ailan Yang   +6 more
doaj   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Safeguarding vitality and cognition: The role of sarcopenia in intrinsic capacity decline among octogenarians from multiple cohorts

The Journal of Nutrition, Health and Aging
Background: Sarcopenia and intrinsic capacity (IC) declines pose significant challenges to healthy aging, particularly in the rapidly growing octogenarian population.
Pi-Shan Hsu, Wei-Ju Lee, Li-Ning Peng, Wan-Hsuan Lu, Lin-Chieh Meng, Fei-Yuan Hsiao, Liang-Kung Chen   +6 more
doaj   +1 more source

The effects of ageing and exercise on skeletal muscle structure and function [PDF]

, 2016
Musculoskeletal ageing is associated with profound morphological and functional changes that increase fall risk and disease incidence and is characterised by age-related reductions in motor unit number and atrophy of muscle fibres, particularly type II ...
Malone, John K.
core  

Individual and joint trajectories of change in bone, lean mass and physical performance in older men. [PDF]

, 2020
BackgroundDeclines in bone, muscle and physical performance are associated with adverse health outcomes in older adults. However, few studies have described concurrent age-related patterns of change in these factors.
Cauley, Jane A, Cawthon, Peggy M, Cummings, Steven R, Drieling, Rebecca, Ensrud, Kristine E, Gill, Thomas M, Hoffman, Andrew R, Kado, Deborah M, Lane, Nancy E, Langsetmo, Lisa, Lapidus, Jodi, McCulloch, Charles E, Orwoll, Eric S, Parimi, Neeta, Stefanick, Marcia L   +14 more
core  

Signal regulatory protein alpha initiates cachexia through muscle to adipose tissue crosstalk [PDF]

, 2019
BACKGROUND: Muscle wasting from chronic kidney disease (CKD) or from defective insulin signalling results in morbidity and, ultimately, mortality. We have identified an endogenous mediator of insulin resistance, signal regulatory protein alpha (SIRPα ...
Dong, Jiangling, Garibotto, Giacomo, Hruska, Keith, Hu, Zhaoyong, Mitch, William E, Thomas, Sandhya S, Verzola, Daniela, Wu, Jiao   +7 more
core   +2 more sources

Sarcopenia in male patients with head and neck cancer receiving chemoradiotherapy: a longitudinal pilot study [PDF]

, 2020
Introduction: Muscle wasting conditions such as sarcopenia may be highly prevalent in advanced head and neck cancer (HNC) patients (16-71%), with these prevalence rates substantially greater in those who have received chemo-radiotherapy (CRT).
Chauhan, Namrata S, Keogh, Justin W L, Meenar, Niranjan, Samuel, Stephen Rajan, Saxena, Pu Prakash   +4 more
core   +1 more source

Additional file 1 of Plasma acylcarnitine in elderly Taiwanese: as biomarkers of possible sarcopenia and sarcopenia

, 2023
Supplementary Material 1: Figure 1. Study flow diagram. This figure shows the number of participants for metabolites analysis. A total of 491 participants enrolled in this study of which 289 subjects were eligible to participate. Then, targeted metabolomics analysis was performed for 289 samples with completed measurement data and divided into four ...
Lo, Chi-Jen, Lin, Chih-Ming, Fan, Chun-Ming, Tang, Hsiang-Yu, Liu, Han-Fang, Ho, Hung-Yao, Cheng, Mei-Ling   +6 more
openaire   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source