Results 111 to 120 of about 162,262 (216)

Switching disease‐modifying therapies in patients with spinal muscular atrophy: A systematic review on effectiveness outcomes

British Journal of Clinical Pharmacology, EarlyView.
With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić, Elvira Meni Maria Gkrinia, Patrick Eustaquio, Andrea Katrin Faour, Dinko Vitezić   +4 more
wiley   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Infusion rate adjustment in enzyme replacement therapy with pabinafusp alfa for mucopolysaccharidosis II

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Enzyme replacement therapy (ERT) for mucopolysaccharidosis II (MPS II) requires long‐term, weekly intravenous infusions often lasting over 3 h each time, which can burden paediatric patients and caregivers and negatively affect their quality of life and treatment compliance.
Kimitoshi Nakamura, Norio Sakai, Hideaki Hirai, Naoko Takasao, Ryo Ibaraki, Tatsuyoshi Yamamoto, Yuji Sato   +6 more
wiley   +1 more source

Effectiveness of the Early Start Denver Model (ESDM) as an early intervention for young children with autism spectrum disorder in clinical settings in Japan: A non-randomized controlled trial. [PDF]

PCN Rep
Tateno Y, Monden R, Kumagai K, Tateno M.
europepmc   +1 more source

Characteristics and temporal trends of EU teratological safety signals and information dissemination to healthcare professionals in the Netherlands—A contribution of the ConcePTION project

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Although regulatory responses to safety signals have been studied, pregnancy‐specific data and their dissemination to medical professionals remain unclear. This study examined the characteristics and temporal trends of teratological safety signals prompting the European Medicines Agency to implement risk minimization measures.
Yrea R. J. van Rijt‐Weetink, Rosanne E. Huisman, Jan‐Peter van Wieringen, H. J. M. J. (Ineke) Crijns, Florence P. A. M. van Hunsel, Anneke L. M. Passier, Sander Borgsteede, A. C. G. (Toine) Egberts, Laura M. Yates, Eugène P. van Puijenbroek   +9 more
wiley   +1 more source

Digital Cognitive Behavioral Therapy for Insomnia Versus Sleep Hygiene Education for Prevention of Perinatal Depression: Protocol for a Randomized Clinical Trial. [PDF]

JMIR Res Protoc
Felder JN, Moran PJ, McClelland B, Mah R, Sorensen C, Ponting C, Sobhani NC, Neuhaus J, Krystal A, Manber R.   +9 more
europepmc   +1 more source

Bridging the Python Training Gap for Bioscientists in Brazil: Improvements and Challenges

Biochemistry and Molecular Biology Education, EarlyView.
ABSTRACT The rapid evolution of high‐throughput technologies in biosciences generates vast and diverse datasets, demanding that bioscientists develop advanced data manipulation and analysis skills. Python, with its versatility and powerful libraries, has become a crucial tool for managing these datasets.
Gustavo Schiavone Crestana, Ubiratan da Silva Batista, Michelli Inácio Gonçalves Funnicelli, Larissa Graciano Braga, Luíza Zuvanov, Rodolfo Bizarria Jr., Raissa Melo de Sousa, Pedro Henrique Narciso Ferreira, Flavia Vischi Winck, Gabriel Rodrigues Alves Margarido, Alessandro de Mello Varani, Diego Mauricio Riaño‐Pachón, Renato Augusto Corrêa dos Santos   +12 more
wiley   +1 more source

Building public health leadership: design, implementation and outcomes of the WHO European autumn school on quality of care and patient safety. [PDF]

Front Public Health
Fonseca VR, Diniz JM, Eleftheria G, Shcherbina Y, Baptista AC, Saldanha Resendes D, Berionni A, Capsaskis L, Tilenbaeva N, Ivankovic D, Myloneros T, Vasileiou C, Marques A, Maliqi B, Weiler G, Sousa P, Breda J.   +16 more
europepmc   +1 more source

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Accuracy Assessment of Planned Versus Actual Trajectories in Robotic-Assisted Spine Surgery Utilizing Perioperative O-Arm CT Scans. [PDF]

Cureus
Dave MB, Panthackel M, Dave BR, Krishnan A, Mayi SC, Rai RR, Vashishtha A, Singh A, Kulkarni SS, Adodariya Y.   +9 more
europepmc   +1 more source