Results 91 to 100 of about 223,105 (281)

Advances in Cancer Immunotherapy for Solid Tumors

Advanced Science, EarlyView.
Cancer immunotherapy for solid tumors is rapidly evolving beyond classical checkpoint blockade toward more precise strategies. Emerging checkpoint targets, bispecific antibodies, antibody–drug conjugate combinations, personalized vaccines, cellular therapies, and engineered cytokines are expanding therapeutic possibilities, while biomarker‐guided ...
Shira Gabizon‐Peretz, Harriet M. Kluger   +1 more
wiley   +1 more source

Diabetes-Related β-Cell Dysfunction Across COVID-19 and Metabolic Syndrome Is More Closely Associated with Chronic Oxidative Stress than with Transient Hypoxia

Diabetology
Aims/hypothesis: Hypoxia and oxidative stress have been implicated in both metabolic syndrome and COVID-19-associated dysglycaemia, yet it remains unclear whether shared or distinct mechanisms underlie β-cell dysfunction across these conditions.
Victoria Tsvetkova, Malvina Todorova, Milena Atanasova, Irena Gencheva, Katya Todorova   +4 more
doaj   +1 more source

Post-acute COVID-19 syndrome and musculoskeletal manifestations: an overview

Research, Society and Development, 2023
Post-acute COVID-19 syndrome (also known as long COVID) refers to the persistence of COVID-19 symptoms for at least four weeks following the acute phase of the disease caused by SARS-CoV-2 infection. This study aims to provide a narrative review of the musculoskeletal manifestations of long COVID-19. While prevalence rates varied among studies, chronic
Nickson Breno Maniçoba, Igor Albuquerque Nogueira, Paulo Henrique da Costa Carlos, Raul Sancho de Carvalho Rocha, Micael Porto Portela Lima, Rafael Alves Cordeiro, Jobson Lopes de Oliveira   +6 more
openaire   +1 more source

“Intrapericardial Approach” for Venous Outflow Reconstruction in Living‐Donor Liver Transplantation for Budd‐Chiari Syndrome: Surgical Techniques and LongTerm Outcomes

Annals of Gastroenterological Surgery, EarlyView.
Unlike deceased‐donor liver transplantation, living‐donor liver transplantation (LDLT) for Budd‐Chiari Syndrome (BCS) presents distinctive challenges in hepatic venous (HV)‐outflow reconstruction because diseased HV–inferior vena cava (IVC) cannot be entirely replaced with healthy donor vessels.
Koichiro Hata, Tetsuya Tajima, Satoshi Ogiso, Shinji Uemoto, Etsuro Hatano   +4 more
wiley   +1 more source

Post-acute COVID-19 outcomes in children requiring hospitalisation

Scientific Reports, 2022
Post-acute COVID-19 causes long term sequalae in adults. This is less well described in children. We performed clinical assessments on a large cohort of children and young people admitted with a positive SARS-CoV-2 RNA swab.
Cara J. Bossley, Ema Kavaliunaite, Katharine Harman, James Cook, Gary Ruiz, Atul Gupta   +5 more
doaj   +1 more source

One-Year Follow-Up Lung Ultrasound of Post-COVID Syndrome—A Pilot Study

Diagnostics, 2022
(1) Background: Millions of people worldwide were infected with COVID-19. After the acute phase of the disease, many suffer from prolonged symptoms, the post-COVID syndrome, especially the phenotype with lung residuals. Many open questions regarding lung
Martin Altersberger, Anna Grafeneder, Yerin Cho, Roland Winkler, Ralf Harun Zwick, Gebhard Mathis, Martin Genger   +6 more
doaj   +1 more source

Better 10‐Year Cerebrovascular Outcome After Transplant Than on Standard‐Care in Sickle Cell Anemia: DREPAGREFFE Trial

American Journal of Hematology, EarlyView.
ABSTRACT Management of cerebral vasculopathy in sickle cell anemia (SCA) includes standard‐care, that is, chronic transfusion (CT) or hydroxyurea, and hematopoietic cell transplantation (HCT). DREPAGREFFE‐1 (December 2010/June 2013), a French multicenter trial, was the first prospective trial comparing standard‐care to match sibling donor (MSD)‐HCT in ...
Francoise Bernaudin, Suzanne Verlhac, Elisabeth Ducros‐Miralles, Cécile Arnaud, Isabelle Genty, Marie Petras, Catherine Paillard, Gonzalo De Luna, Benoit Meunier, Isabelle Thuret, Annie Kamdem, Corinne Pondarré, Giovanna Cannas, Christelle Chantalat‐Auger, Nadia Firah, Sophie Pertuisel, Laure Joseph, Florence Missud, Mariane de Montalembert, Corinne Guitton, Claire Pluchart, Valentine Brousse, Monique Elmaleh, Vincent Gajdos, Emmanuella Leveillé, Ekaterina Belozertseva, Mabel Gaba, Catherine Poirot, Virginie Barraud‐Lange, Philippe Chadebech, France Pirenne, Myriam Bernaudin, Bénédicte Neven, Pierre Frange, Marie Angoso, Karima Yakouben, Bénédicte Bruno, Nathalie Dhédin, Jean‐Hugues Dalle, Regis Peffault Delatour, Camille Jung   +40 more
wiley   +1 more source

Personal HealthCare of Things: A novel paradigm and futuristic approach

CAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract This study provides an investigative approach and offers a complete review of research on Internet of Medical Things (IoMT), describing the progress in general and highlighting the research issues, trends, and future aspects of IoMT. Exploring a research strategy for IoMT systems is vital as the need for IoT in healthcare grows. By aggregating
Surbhi Gupta, Mohammad Shabaz, Ankur Gupta, Abdullah Alqahtani, Shtwai Alsubai, Isaac Ofori   +5 more
wiley   +1 more source

Endothelial Dysfunction in COVID-19: A Unifying Mechanism and a Potential Therapeutic Target

Biomedicines, 2022
The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a worldwide emergency, until the declaration of the pandemic in March 2020.
Pasquale Ambrosino, Ilenia Lorenza Calcaterra, Marco Mosella, Roberto Formisano, Silvestro Ennio D’Anna, Tiziana Bachetti, Giuseppina Marcuccio, Brurya Galloway, Francesco Paolo Mancini, Antimo Papa, Andrea Motta, Matteo Nicola Dario Di Minno, Mauro Maniscalco   +12 more
doaj   +1 more source

Targeted Anti‐IL‐1 Immunomodulatory Therapy in Pediatric Onset PPP1R13L‐Related Arrhythmogenic Cardiomyopathy

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Autosomal recessive loss‐of‐function variants in PPP1R13L cause an ultra‐rare cardiocutaneous syndrome characterized by rapidly progressive arrhythmogenic cardiomyopathy (ACM). PPP1R13L encodes iASPP, which has two potentially overlapping mechanisms driving ACM as both a regulator of NFκB‐mediated inflammation and a binding partner within the ...
Aaron Renberg, Savannah Coppersmith, Owen Merritt, Amer Heider, Adam Helms, Thomas Michniacki, Jack Luxford, Sarah Josephi‐Taylor, Philip Roberts, Joshua Meisner   +9 more
wiley   +1 more source