Results 111 to 120 of about 223,105 (281)
Prone Position in COVID-19 Patients With Severe Acute Respiratory Distress Syndrome Receiving Conventional Oxygen Therapy: A Retrospective Study.
, 2021 Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which emerged in Wuhan (China) in December 2019.1 Although most cases are mild, nearly 20% of patients require hospitalization.2 Despite ...Suarez-Carantoña, Cecilia, Coloma-Conde, Ana, Maria Garcia-Garcia, Gema, SEMI-COVID-19 Network, Nicolas Alcala-Pedrajas, Jose, Rubio-Rivas, Manuel, Ferreiro-Mazon Jenaro, Maria Mercedes, Pesqueira-Fontan, Paula M., Javier Carrasco-Sanchez, Francisco, Gómez-Huelgas, Ricardo, Luis Garcia-Klepzig, Jose, Otero-Perpiña, Barbara, Arnalich-Fernandez, Francisco, Costo-Muriel, Clara, Escobar-Sevilla, Joaquin, Rodriguez-Cortes, Pablo, Loureiro-Amigo, Jose, Garcia-Garcia, Gema Maria, Artero, Arturo, Carrasco-Sanchez, Francisco Javier, Alcala-Pedrajas, Jose Nicolas, SEMI COVID-19 Network, Manzano-Espinosa, Luis, Sanchez-Diaz, Cristina, Coduras-Erdozain, Ainara, Pesqueira-Fontan, Paula M, Jimenez-Torres, Jose, Ramos-Rincon, Jose-Manuel, Oriol, Isabel, Fiteni-Mera, Isabel, Garcia-Klepzig, Jose Luis, Vargas-Parra, Derly +31 morecore +1 more sourceDecoding RNA regulation: Challenges and opportunities for RNA‐based therapies in Europe
British Journal of Clinical Pharmacology, EarlyView.Abstract RNA‐based medicinal products represent a promising frontier in personalised medicine, offering sequence‐specific disease targeting at various molecular levels, yet their clinical translation in the European Union (EU) may be hindered by regulatory uncertainty around definitions and evidence requirements; this study therefore aims to identify ...Olivia C. Lewis, Christine Leopold, Joyce M. Hoek, Raymond M. Schiffelers, Marie L. De Bruin +4 morewiley +1 more sourceSex differences in use of low tidal volume ventilation in COVID-19—insights from the PRoVENT–COVID study
, 2021 The purpose of this study was to compare and understand differences in the use of low tidal volume ventilation (LTVV) between females and males with acute respiratory distress syndrome (ARDS) related to coronavirus disease 2019 (COVID-19). This is a post-Neto, Ary Serpa, Schultz, Marcus J, ‘PRactice of VENTilation in COVID-19’ (PRoVENT-COVID) Collaborative Group, Paulus, Frederique, Nijbroek, Sunny G. L. H., Schultz, Marcus J., Swart, Pien, Nijbroek, Sunny GLH +7 morecore +1 more sourceSubstrate‐Selective Inhibition of the SARS‐CoV‐2 Papain‐Like Protease: Inhibition of Hydrolysis of Human Over Viral Substrates
Chemistry – A European Journal, EarlyView.The SARS‐CoV‐2 papain‐like protease (PLpro) is a medicinal chemistry target. Here we report mass spectrometry assays employing oligopeptide substrates based on the sequences of the viral polyproteins 1a/1ab and on an ISG15‐modified human protein, which enabled the identification of substrate‐selective PLpro inhibitors.Sakshi Sharma, Peter A. C. Wing, Wojtek Treyde, Shyam Basak, Simeon D. Draganov, Taylah Andrews‐Clark, Eidarus Salah, Petra Lukacik, Claire Strain‐Damerell, Adán Pinto‐Fernández, Martin A. Walsh, Fernanda Duarte, Christopher J. Schofield, Lennart Brewitz +13 morewiley +1 more sourceThe role of cardiac acoustic biomarkers in monitoring patients with heart failure: A systematic literature review
ESC Heart Failure, Volume 12, Issue 2, Page 980-997, April 2025.Abstract
Heart failure (HF) creates a considerable clinical, humanistic and economic burden on patients and caregivers as well as on healthcare systems. To attenuate the significant burden of HF, there is a need for enhanced management of patients with HF.Javed Butler, Malcolm Brown, Philippe Prokocimer, Ashley C. Humphries, Sophie Pope, Olivia Wright, Jun Su, Osama Elnawasany, Bogdan Muresan +8 morewiley +1 more sourceSafety and outcome of revascularization treatment in patients with acute ischemic stroke and COVID-19: the Global COVID-19 Stroke Registry
, 2023 Background and ObjectivesCOVID-19-related inflammation, endothelial dysfunction, and coagulopathy may increase the bleeding risk and lower the efficacy of revascularization treatments in patients with acute ischemic stroke (AIS). We aimed to evaluate the Mahmoud, M., Tiu, C., Krajina, A., Maia, C., Michael, M., Beyeler, M., Maali, L., Seo, K.D., Coutinho, J.M., Eichlová, Z., Audebert, H.J., Fuentes, B., Bianco, G., Vuillier, F., Simister, R., Radu, R.A., De Meris, J., Melo, T.P.E., Forlivesi, S., Wrona, P., Gloyer, N.O., Arnold, M., Bandzarewicz, A., Varela, R., Obara, K., Bartosik-Psujek, H., Martins, R.T., Terecoasa, E.O., Stolp, J., Stepien, A., Cereda, C.W., Nalleballe, K., Sieczkowski, B., Gioia, S. la, Masoud, H., Min, J., Zivelonghi, C., Amaya, P., Strambo, D.N., Mansour, O.Y., Havlicek, R., Schwarz, G., Ferrari, J., Abdelkhalek, H., Nguyen, T., Nunes, A.P., Cruz-Culebras, A., Nogueira, R.G., Calleja-Castaño, P., Paula, A., Renú, A., Urbanowski, P., Carrera, E., Jíra, M., Guzinski, M., Dusart, A., Staszewski, J., Vandervorst, F., Ismail, I.I., Castro, P., Broocks, G., Hernández-Fernández, F., Scollo, S.D., Bilik, M., Bach, I., Global Covid-19 Stroke Registry, Nagendra, S., Panea, C., Sykora, M., Sobieszak-Skura, P., Ferrarese, C., Wasilewski, G., Beretta, S., Mikulik, R., Barrientos Guerra, J.D., See, I., Olserová, A., Piotin, M., Stolze, L.J., Petrescu, S., Ghoreishi, A., Ostos, F., Malheiro, S., Sangalli, D., Pérez-de-la-Ossa, N., Meira, T., Diamanti, S., Vera, R., Baumgartner, P., Ayo-Martin, O., Roubec, M., Machado, R., García-Madrona, S., Cviková, M., Tiu, V., Khawaja, A.M., Altersberger, V., Sramek, M., Lemmens, R., Rodríguez-Vázquez, A., Tomek, A., Ostry, S., Khandelwal, P., Siebert, E., Ong, M., Magriço, M., Sibon, I., Gross, H., Maïer, B., Perez-Sanchez, S., Schaefer, J.H., Bonati, L., Palouskova, H., Meris, J. de, Skoloudík, D., Machado, E., Rentzos, A., Flottmann, F., Skoda, O., Homa, T., Ntaios, G., Dorobat, B., Wetzel, S., Babici, D., Abbas, R., Gentile, M., Min, J.Y., Hlaing, T., Tejada-Meza, H., Vodret, F.R., Maly, P., Pezzini, A., Sienkiewicz-Jarosz, H., Abraham, M.G., Rigual, R., Nordanstig, A., Martín-Jiménez, P., Sabetay, S.I., Gensicke, H., El Naamani, K., Caetano, R., Cano-Nigenda, V., Marto, J.P., Rutkowska, I., Alonso-de-Leciñana, M., Hruby, R., Pereira, L., Guerra, J.D.B., Werring, D., Salmeen, A., Escalard, S., Wlodarczyk, E., Tomaszewska-Lampart, I., Switonska, M., Kaur, N., Chamorro, A., Zwiernik, J., Dias, M.C., Sabben, C., Pansky, M., Al-Hashel, J., Azevedo, E., Migliaccio, L., Alves, J.N., Rutgers, M.P., Montaner, J., Nolte, C., Liegey, J.S., Bellante, F., Flores-Pina, B., Ferreira, P., Naamani, K. el, Chebl, A., De Raedt, S., Tjoumakaris, S., Guilmot, A., El-Samahy, H., Kovar, M., Fiksa, J., Wijngaard, I. van den, Mencl, P., Ozdemir, A., Czlonkowska, A., Serrano-Ponz, M., Strambo, D., Lang, W.L., Negrila, A., Knoflach, M., Wegener, S., Muñoz-Narbona, L., Hurtikova, E., Nowak, M., Bolognese, M., Demeestere, J., Peters, N., Sajeva, G., Ramos, J.N., Jood, K., Trakal, L., Karlinski, M.A., Frisullo, G., Hovingh, M., Onteddu, S., Nederkoorn, P., Dorobek, M., Arango, A., Pinho E Melo, T., Salerno, A., Cappellari, M., Mohamed, G.A., Khan, M., Krajícková, D., Slowik, A., Rodrigues, M., Herzig, R., Correia, M.A., Arauz, A., Machi, P., Cuisenier, P., Gizewski, E.R., Sagarra-Mur, D., Sawczynska, K., Jurak, L., Abdalkader, M., Charbonnier, G., Matute, M.C., Vences, M.A., Pereira-Fonseca, A., Bohmann, F.O., Wiacek, M., Simunek, L., Bochynska, A., Nowakowska-Kotas, M., Ferreira-Pinto, J., Seners, P., van den Wijngaard, I., Tsai, J.P., Gaikwad, A., Tsai, J., Zedde, M., Ribeiro, L., Lang, W., Pernicka, M., Jansky, P., Georgiopoulos, G., Llanos, N., Vinklárek, J., La Gioia, S., Debiec, A., Nguyen, T.N., Legris, L., Segura, T., Zielinska-Turek, J., Kristoffersen, E.S., Klein, P., Jabbour, P., Díaz-Otero, F., Pascarella, R., Sessa, M., Labuz-Roszak, B.M., Albuquerque, L., Mayer-Suess, L., Rajamani, K., Hakemi, M., Zini, A., Slovák, M., Sargento-Freitas, J., González-Ortega, G., Marnat, G., Budrewicz, S., Raedt, S. de, Rocha, M., Yalung, P.M., Marcheselli, S., Díez-Tejedor, E., Araujo, A.P., Michel, P. +276 morecore +1 more sourceEpidemiology of hospitalized heart failure in France based on national data over 10 years, 2012–2022
ESC Heart Failure, Volume 12, Issue 2, Page 1283-1294, April 2025.Abstract Aims
We aim to describe the incidence of HF hospitalization in France in the post‐pandemic era, the prevalence of HF cases and patients' characteristics, management and outcomes while focusing on sex, age and socio‐economic differences and to analyse time‐trends between 2012 and 2022.Valérie Olié, Richard Isnard, Françoise Pousset, Clémence Grave, Jacques Blacher, Amélie Gabet +5 morewiley +1 more source
