Results 91 to 100 of about 2,841,334 (307)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Session:management of drainage near source – disconnection/minimise surface water entering public drainage [PDF]
, 2008 Many combined sewer networks are currently constrained due to lack of capacity. Surface water entering the network may have an impact on the local environment by causing additional spills from Combined Sewer Overflows (CSOs) and flooding events. With the
Blackwood, David J. +2 more
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Nonpoint Source Pollution Control in the City of Austin [PDF]
, 1991 This report mentions the presence of rooted aquatic plants in the deltas of Waller Creek.Waller Creek Working ...
Parrish, John H., Stecher, Stephen L.
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecules, 2018 Metabolic syndrome (MetS) is characterized by interconnected factors related to metabolic disturbances, and is directly related to the occurrence of some diseases such as cardiovascular diseases and type 2 diabetes.
Priscila Silva Figueiredo +7 more
doaj +1 more source
Town of Hampton Stormwater Management PREP Natural Resources Outreach Coalition Grant Final Project Report [PDF]
, 2010 PREP provided $3,500 towards the project which was matched by municipal funds to pay for consulting advice on improving the regulations. The Planning Board provided exceptional in-kind match on the project, with many hours of work spent by a volunteer ...
Natural Resources Outreach Coalition +1 more
core +2 more sources
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Smart distribution board overload detector by using microcontroller [PDF]
, 2020 A statistic by Economic Planning Unit (EPU) on the electricity growth in Malaysia has shown an increment in line with economic growth [1]. In line with government policies, the energy supply industry has been molding itself to cater to the rapid ...
Ismail, Muhammad Nafis +4 more
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