Results 211 to 220 of about 545,904 (303)

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, EarlyView.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

The UME-to-GME Transition Toolkit: Guidance for Stakeholders Across Medical Education. [PDF]

J Grad Med Educ
Sheets ZC, Behel J, Blumberg M, Cantone RE, Green E, Kaplan E, Moreland C, Ramy M, Ridgeway LS, Steelquist E, Verduzco-Gutierrez M, Passiment M, Charnsangavej N.   +12 more
europepmc   +1 more source

Post graduate education.

Arquivos brasileiros de cardiologia, 1998
openaire   +1 more source

Oxygen Vacancy‐Mediated Bi─O Unsaturation Coordination in BiOCl for Efficient Photocatalytic Water Purification

Advanced Science, EarlyView.
The incorporation of oxygen vacancies (OVs) presents a viable strategy for fine‐tuning the photocatalytic prowess of BiOCl. A reliable hydrogen annealing reduction technique is employed to precisely design OVs, thereby optimizing the light absorption capacity, as well as the efficiency of carrier migration and separation in BiOCl.
Shuaihao Ma, Jianglong Kong, Shidong Zhang, Wentao Li, Ling Yan, Deng Long, Xinglin Yu, Dawei Wang, Zheng Han, Sihan Ma, Lin Wang, Guang Ran   +11 more
wiley   +1 more source

A prospective, non-randomized, interventional trial of thalidomide and hydroxyurea combination therapy in children with non-transfusion-dependent thalassemia

Pediatric Hematology Oncology Journal
Malav Thakkar, Amita Trehan, Reena Das, Nushrat Shafiq, Deepak Bansal   +4 more
doaj   +3 more sources

Diagnostic and Procedural Imaging Curricula in Musculoskeletal Physical Therapist Residency and Fellowship Education. [PDF]

Physiother Res Int
Nelson EO, Goetz-Sutinen EC, Amborn TAJ, Gerke DA.   +3 more
europepmc   +1 more source

Matrix Stiffness Induces Endothelial Network Senescence

Advanced Science, EarlyView.
Using a 3D human in vitro model that decouples mechanical stress from inflammatory or biochemical signals, matrix stiffening induces a senescence phenotype in endothelial networks. This mechano‐induced senescence activates Notch signaling, and pharmacologic Notch inhibition attenuates this stiffness‐induced senescence.
Jiyeon Song, Alexandra N. Rindone, Ya Guan, Connor D. Amelung, Prarthana Sanjay Daswani, Jennifer H. Elisseeff, Sharon Gerecht   +6 more
wiley   +1 more source

WCN25-1678 HIGH DOSE ERYTHROPOIETIN VERSUS DESIDUSTAT FOR TREATMENT OF ANEMIA IN PATIENTS OF CHRONIC KIDNEY DISEASE HAVING INADEQUATE RESPONSE TO WEIGHT BASED ERYTHROPOIETIN DOSE: PROSPECTIVE OBSERVATIONAL STUDY

Kidney International Reports
Smita Divyaveer, Harbir Singh Kohli, Deepy Zohmangaihi, Nabhajit Mallik, Kushal Kekan, Arun Prabhahar, Madhuri Kashyap, Kanchan Prajapati   +7 more
doaj   +1 more source

Exploring facilitators and barriers to effective practice among new graduate occupational therapists working with children and families: A scoping review. [PDF]

Aust Occup Ther J
Barnes A, Burritt L, Chilman LB, Meredith PJ.   +3 more
europepmc   +1 more source

Ultrasound‐Recharged Sub‐Nanometer Palladium Catalysts for on‐Demand and Self‐Terminating Bioorthogonal Prodrug Activation in Cancer Therapy

Advanced Science, EarlyView.
Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia, Lei Liu, Shuang Jin, Guangxu Fang, Chang Yu, Yunyun Wu, Lunli Xiang, Hongrui Zhu, Zhenqiang Wang, Jixi Zhang   +9 more
wiley   +1 more source