Results 41 to 50 of about 226,138 (314)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Performance evaluation of Unmanned Drum Seeder (UDR) over Manual Drum Seeder (MDR) using Taguchi design by Minitab

Discover Agriculture
In response to operational issues impacting seeding performance, occupational hazards, cumbersome and labor-intensive operation of manual drum seeder (MDR), the unmanned drum seeder (UDR) was developed.
Bharath Kumar Komatineni, Sangram Kishore Satpathy, Utkarsh Dwivedi, Asif Beg, Lakshminath Badra, Amit Gupta   +5 more
doaj   +1 more source

The effects of leaf litter treatments, post-harvest urea and omission of early season fungicide sprays on the overwintering of apple scab on Bramley’s Seedling grown in a maritime environment. [PDF]

, 2010
peer-reviewedThe theory that orchards with zero or low levels of apple scab post harvest do not need scab protection at the start of the next growing season was evaluated under Irish conditions.
Cooke, L.R., Mac an tSaoir, S., McCracken, A.R.   +2 more
core  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Antimicrobial properties and potential applications of flour mix of mustard and fenugreek seeds on cow butter in Mekelle, Tigray, Ethiopia

Discover Food
This study focused on the reference to the flour as natural anti-microbial additives of mustard and fenugreek seed flour mixes as real spoilage microorganisms.Particularly in their ability to inactivate S. aureus and E. coli, which are used as indicators
Ftwi Gebremedhin Kidane, Lijalem Tareke Weldeabezgi, Teklebrhan Welday Atsbha, Gebrehiwot Gidey Gebrekrstos   +3 more
doaj   +1 more source

Factors that affect proliferation of Salmonella in tomatoes post-harvest: the roles of seasonal effects, irrigation regime, crop and pathogen genotype [PDF]

, 2013
MAIN OBJECTIVES: Fresh fruits and vegetables become increasingly recognized as vehicles of human salmonellosis. Physiological, ecological, and environmental factors are all thought to contribute to the ability of Salmonella to colonize fruits and ...
A Lapidot, A Schikora, AL Iniguez, AL Moyne, AM Semenov, Andrée S. George, AV Semenov, B Steeb, C Benard, CT Parker, D Aruscavage, D Aruscavage, D Bumann, E Gutierrez-Rodriguez, G Lopez-Velasco, G Rastogi, George J. Hochmuth, Jason T. Noel, JD Barak, JD Barak, JD Barak, Jerry Bartz, JT Noel, JT Noel, L Gorski, LJ Harris, M Islam, M Islam, Massimiliano Marvasi, Max Teplitski, MC Erickson, MC Erickson, MC Erickson, Mihai C. Giurcanu, MM Klerks, MQ Carter, MQ Carter, MT Brandl, MT Brandl, RK Kar, S Park, S Thompson, SK Greene, TR Williams, WJ Zaragoza, X Shi, X Shi, Y Dong, Yung-Fu Chang   +48 more
core   +2 more sources

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Multiple Antibiotic-Resistant, Extended Spectrum-β-Lactamase (ESBL)-Producing Enterobacteria in Fresh Seafood

Microorganisms, 2017
Members of the family Enterobacteriaceae include several human pathogens that can be acquired through contaminated food and water. In this study, the incidence of extended spectrum β-lactamase (ESBL)-producing enterobacteria was investigated in fresh ...
Asem Sanjit Singh, Manjusha Lekshmi, Sreepriya Prakasan, Binaya Bhusan Nayak, Sanath Kumar   +4 more
doaj   +1 more source

Isolation of Shiga toxin-producing Escherichia coli harboring variant Shiga toxin genes from seafood [PDF]

Veterinary World, 2018
Background and Aim: Shiga toxin-producing Escherichia coli (STEC) are important pathogens of global significance. STEC are responsible for numerous food-borne outbreaks worldwide and their presence in food is a potential health hazard.
Sreepriya Prakasan, Parmanand Prabhakar, Manjusha Lekshmi, Binaya Bhusan Nayak, Sanath Kumar   +4 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source