Results 21 to 30 of about 134,298 (266)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Investigating the Antioxidant Potential of Mango Seed Kernel Polyphenols: Extraction and Optimization Strategies

Foods
Mango seed kernels, an underutilized by-product of the mango pulping industries, are a rich supplier of metabolites, specifically phenolic and flavonoid compounds. These compounds have potential health benefits.
Poonam Choudhary, Sandeep P. Dawange, Thingujam Bidyalakshmi, Ramesh Chand Kasana, Kairam Narsaiah, Bhupendra M. Ghodki   +5 more
doaj   +1 more source

Effect of Shoot Pruning on Growth, Flowering and Fruiting Characteristics of Different Guava (Psidium Guajava L.) Cultivars

International Journal of Fruit Science, 2022
A field trial was conducted to study the effect of shoot pruning on growth, flowering and fruiting characteristics of different guava cultivars. The experiment was carried out during Jan. 2018 to June 2019. The experiment was laid out in Randomized Block
Santhoshkumar G M, Nilesh Bhowmick, Aditi Chakraborty, Amarendra Nath Dey, Arunava Ghosh, Puspendu Dutta, Prahlad Deb, Novin Chamling, Nim Tshering Sherpa, Bidyarani Devi Senjam   +9 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of Packaging Materials on Lettuce (Lactuca sativa var. capitata) Chemical Quality Under Cold Storage

International Journal of Food Science
Lettuce is a perishable vegetable with a short shelf life, which leads to detrimental changes in texture, physiological processes, and enzymatic activity during postharvest storage.
Vu Thi Kim Oanh, Tolcha Techane Alemu
doaj   +1 more source

Trends over the last 25 years and future research into smart packaging for food: A review

Future Foods, 2023
The review study intends to investigate global contributions, analyze current trends in smart packaging, and project the future of this area. A bibliometric analysis was undertaken to analyze the application of smart packaging comprehensively ...
Andi Dirpan, Serli Hatul Hidayat, Muspirah Djalal, Andi Fadiah Ainani, Dewi Sisilia Yolanda, Kasmira, Matthew Khosuma, Gloria Tiara Solon, Nadia Ismayanti   +8 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Comprehensive Review of Antibiotics and Antimicrobial Resistance in the Aquaculture Sector of the World and Bangladesh

International Journal of Microbiology
Antibiotics are molecules produced by a microbe to inhibit the growth of another microbe. Due to prolonged improper use, the situation in which these antibiotics do not work effectively on these microbes is termed antibiotic resistance or antimicrobial ...
Shama Afroze, Md. Faisal, Mohammed Nurul Absar Khan, Hrishika Barua   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source