Results 101 to 110 of about 30,532 (266)

Additional hepatic artery embolization after liver venous deprivation for right hepatectomy: A case report

Radiology Case Reports
Post hepatectomy Liver Failure (PHLF) is a fatal complication, especially after major liver resection. Insufficient remnant liver volume is a common cause of postoperative liver failure.
Anh T Pham, Quoc H Dang, Cuong M Truong, Phuong H Trinh, Lam D Vu, Thinh D Nguyen, Thang Q Tran, An TM Nguyen, Khue K Dang   +8 more
doaj   +1 more source

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Optical Biomedical Imaging Reveals Criteria for Violated Liver Regenerative Potential

Cells, 2023
To reduce the risk of post-hepatectomy liver failure in patients with hepatic pathologies, it is necessary to develop an approach to express the intraoperative assessment of the liver’s regenerative potential.
Svetlana Rodimova, Nikolai Bobrov, Artem Mozherov, Vadim Elagin, Maria Karabut, Ilya Shchechkin, Dmitry Kozlov, Dmitry Krylov, Alena Gavrina, Vladimir Zagainov, Elena Zagaynova, Daria Kuznetsova   +11 more
doaj   +1 more source

F13A1‐Mediated Macrophage Activation Promotes MASH Progression via the PKM2/HIF1A Pathway

Advanced Science, EarlyView.
In fatty liver disease, hepatocytes exposed to palmitate release S1P, which activates calcium signaling in macrophages. Elevated calcium enhances the activity of F13A1, driving PKM2 dimerization. The PKM2 dimers cause Warburg effect, translocate to the nucleus, cooperate with HIF1A, and upregulate IL1B expression, ultimately promoting classical ...
Qianrang Lu, Meiching Ong, Xuewen Yi, Muqiong Xing, Xinyao Tian, Ke Zhang, Ling Lu, Hao Wang, Xiaohan Lin, Jun Fang, Aibo Mu, Jiaying Cao, Jingyu Jiang, Feng Gao, Hongjun Li, Baohong Wang, Qi Ling   +16 more
wiley   +1 more source

Results of Radical Surgical Treatment of Cholangiocarcinoma [PDF]

, 2017
Radical operations of cholangiocarcinomas are connected with the great number of post-operative complications, and lethality reaches 15-30 %. The most debatable questions remain the choice of the operation type depending on localization and spreading of ...
Avdosyev, Y. (Yuriy), Boyko, V. (Valeriy), Sochnieva, A. (Anastasiia)   +2 more
core   +2 more sources

Retrospective analysis of post-operative coagulopathy after major hepatic resection at a tertiary care centre in Northern India

Indian Journal of Anaesthesia, 2017
Background and Aims: Hepatic resection is a major surgery associated with intraoperative massive fluid shifts, blood loss, haemodynamic instability and risk of development of post-hepatectomy liver failure.
Shweta A Singh, P Vivekananthan, Ankur Sharma, Sandeep Sharma, Kishore GS Bharathy   +4 more
doaj   +1 more source

Noninvasively Assessed Portal Hypertension Grade Predicts Post-Hepatectomy Liver Failure in Patients With HepatocellCarcinoma: A Multicenter Study

Frontiers in Oncology, 2022
PurposeTo determine the predictive value of portal hypertension (PH) for the development of post-hepatectomy liver failure (PHLF) in patients with hepatocellular carcinoma (HCC).Patients and methodsThis study enrolled a total of 659 patients with HCC ...
Jitao Wang, Jitao Wang, Zhanguo Zhang, Dong Shang, Jinlong Li, Chengyu Liu, Peng Yu, Mingguang Wang, Dengxiang Liu, Hongrui Miao, Shuang Li, Biao Zhang, Anliang Huang, Yewei Zhang, Shubo Chen, Xiaolong Qi   +15 more
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Prediction of small for size syndrome after extended hepatectomy: Tissue characterization by relaxometry, diffusion weighted magnetic resonance imaging and magnetization transfer. [PDF]

PLoS ONE, 2018
This study aimed to monitor the course of liver regeneration by multiparametric magnetic-resonance imaging (MRI) after partial liver resection characterizing Small-for-Size Syndrome (SFSS), which frequently leads to fatal post-hepatectomy liver failure ...
Christian Eberhardt, Moritz C Wurnig, Andrea Wirsching, Cristina Rossi, Idana Feldmane, Mickael Lesurtel, Andreas Boss   +6 more
doaj   +1 more source

Hepatectomy risk assessment with functional magnetic resonance imaging (HEPARIM)

BMC Cancer, 2021
Background Post hepatectomy liver failure (PHLF) remains a significant risk in patients undergoing curative liver resection for cancer, however currently available PHLF risk prediction investigations are not sufficiently accurate.
Mohamed Elsharif, Matthew Roche, Daniel Wilson, Susmita Basak, Ian Rowe, Dhakshina Vijayanand, Richard Feltbower, Darren Treanor, Lee Roberts, Ashley Guthrie, Raj Prasad, Mark S. Gilthorpe, Magdy Attia, Steven Sourbron   +13 more
doaj   +1 more source