Results 91 to 100 of about 7,385,684 (193)

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

A Novel Bile Duct-Saving Portal Ligation Technique for Subtotal Hepatectomy Survival Operations in Rats

Livers
Background: Creating a model for acute liver failure in animal models is essential for research on liver regeneration and cancer. Current surgical techniques allow for a maximum of 80% partial hepatectomy in rats, with low survival rates due to poor ...
Kush Savsani, Anjelica Alfonso, Ester Jo, Andrew Park, Seung Duk Lee   +4 more
doaj   +1 more source

Hepatitis B in Organ Transplantation—Current Evidence and Clinical Gaps

Transplant Infectious Disease, EarlyView.
ABSTRACT Over the past several decades there have been significant advances in nucleos(t)ide analogue (NA) antiviral therapy for hepatitis B virus (HBV) and global expansion of primary prevention through immunization. Despite this, HBV remains a leading cause of chronic liver disease globally, affecting over 250 million people.
Oscar A. Fernandez‐Garcia, Britta L. Hirsch, Irene A. Abela, Karen E. Doucette   +3 more
wiley   +1 more source

Post hepatectomy liver failure – A comprehensive review of current concepts and controversies

Annals of Medicine and Surgery, 2018
Post hepatectomy liver failure (PHLF) comprises of a conundrum of symptoms and signs following major hepatic resections. The pathophysiology essentially revolves around disruption of the normal hepatocyte regeneration and disturbed liver homeostasis. Prompt identification of the pre-operative predictors of PHLF in the form of biochemical parameters and
S. Ray, N.N. Mehta, A. Golhar, S. Nundy
openaire   +2 more sources

Regional quantification of metabolic liver function using hyperpolarized [1-13C] pyruvate MRI

Scientific Reports
Assessment of liver function is essential before partial hepatectomy to predict the risk of post hepatectomy liver failure, a severe and life-threatening complication.
Uffe Kjaergaard, Andrea Lund, Mohsen Redda, Mattias Hedegaard Kristensen, Malene Aastrup, Nikolaj Bøgh, Kim Sivesgaard, Michael A. Ohliger, Daniel B. Vigneron, Lotte Bonde Bertelsen, Aage Kristian Olsen Alstrup, Esben Søvsø Szocska Hansen, Frank Viborg Mortensen, Christoffer Laustsen   +13 more
doaj   +1 more source

Transpapillary/Transfistular Drainage for Two Refractory Postoperative Right‐Lobe Bilomas: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT We report a case of two refractory postoperative right‐lobe bilomas that were successfully treated with transpapillary/transfistular (TP/TF) drainage. A 57‐year‐old man developed two bilomas (segments 6 and 7) after repeated hepatectomy for colorectal liver metastases.
Fumitaka Niiya, Naoki Tamai, Jun Noda, Tetsushi Azami, Yuichi Takano, Masatsugu Nagahama   +5 more
wiley   +1 more source

Electroacupuncture Promotes Liver Regeneration by Activating DMV Acetylcholinergic Neurons‐Vagus‐Macrophage Axis in 70% Partial Hepatectomy of Mice

Advanced Science
Lack of liver regenerative capacity is the primary cause of hepatic failure and even mortality in patients undergoing hepatectomy, with no effective intervention strategies currently available.
Liu Yang, Yanyu Zhou, Zhaoshuai Huang, Wenxuan Li, Jiacheng Lin, Weifan Huang, Yali Sang, Fang Wang, Xuehua Sun, Jiangang Song, Hailong Wu, Xiaoni Kong   +11 more
doaj   +1 more source

Successful Management of a Completely Disconnected Bile Leak After Hepatectomy Using Endoscopic Ultrasound‐Guided Transluminal Drainage of a Biloma: A Case Report

DEN Open, Volume 7, Issue 1, April 2027.
ABSTRACT Post‐hepatectomy bile leak is a common postoperative complication. It usually resolves spontaneously but may be refractory. In cases of completely disconnected bile ducts, endoscopic retrograde cholangiopancreatography (ERCP)–guided drainage is often technically difficult, and invasive additional procedures may be required.
Tatsuki Tanaka, Kohsaku Ohnishi, Hiroshi Yukimoto, Akino Okamoto, Takafumi Tanimoto, Soichiro Mori, Motohiro Hirao, Masanori Tsujie, Atsushi Hosui, Naoki Hiramatsu   +9 more
wiley   +1 more source

Recent Advances in Functional Liver Volumetry: Emphasis on 99mTc‐GSA SPECT/CT Fusion Imaging

Annals of Gastroenterological Surgery
Functional assessment of the future liver remnant (FLR) has become increasingly important for improving the safety of major hepatectomy. Conventional evaluation based on computed tomography (CT) volumetry estimates anatomical liver volume but does not ...
Toru Beppu, Toshiro Masuda, Yasunori Nagayama, Hidetoshi Nitta, Hiromitsu Hayashi   +4 more
doaj   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, Volume 13, Issue 61, 3 November 2026.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source