Results 101 to 110 of about 7,385,684 (193)

Developing and validating a pre-operative risk score to predict post-hepatectomy liver failure [PDF]

, 2019
Background: Post hepatectomy liver failure (PHLF) is a serious complication in patients undergoing liver resection. This study hypothesized that a new pre-operative risk score developed through statistical modeling to predict PHLF could be used to ...
Marudanayagam R., Hodson J., Roberts K. J., Mirza D. F., Isaac J., Muiesan P., Dasari B. V. M., Sutcliffe R. P.   +7 more
core   +1 more source

Human umbilical cord mesenchymal stem cell exosomes promote liver regeneration by inducing CD206+ macrophage polarization and suppressing ZBP1 PANoptosis

Scientific Reports
Post-hepatectomy liver failure (PHLF) is a serious complication after partial hepatectomy without approved therapies to safely enhance liver regeneration.
Xiaojing Song, Xiao Tang, Yao Liu, Songtian Liu, Jian Ma, Yi Shao   +5 more
doaj   +1 more source

Preoperative FIB‐4 Index as a Potential Factor Associated With Severe Postoperative Complications and Endogenous Organ Failure After Hepatectomy for Hepatocellular Carcinoma

Annals of Gastroenterological Surgery, Volume 10, Issue 6, Page 1798-1809, November 2026.
This study demonstrates that a preoperative FIB‐4 index ≥ 5.0 independently predicts severe complications and endogenous organ failure (EOF) following hepatectomy for hepatocellular carcinoma. By capturing structural liver fragility and systemic vulnerability, the FIB‐4 index enhances surgical risk stratification beyond traditional functional markers ...
Masanori Nakamura, Yukiyasu Okamura, Osamu Aramaki, Nao Yoshida, Yusuke Mitsuka, Hayato Abe, Shunsuke Yamagishi, Yasuhiro Okumura, Kyongsun Pak, Shinobu Masuda   +9 more
wiley   +1 more source

Three-dimensional bioprinted hiHeps hepatorganoids with enhanced hepatic functions for the treatment of liver failure and promotion of liver regeneration

Bioactive Materials
The intricate architecture of the liver, combined with its limited regenerative ability in severe injury, has spurred the development of innovative approaches for hepatic repair and functional restoration.
Zhichao Ye, Jianing Yan, Yuheng Wang, Yiheng Lin, Chao Wang, Quan Yang, Tong Ji, Enjie Zhou, Qiang Zheng, Danyang Zhong, Yuyang Yuan, Tingting Yan, Ziyuan Wang, Jun Yin, Xiujun Cai, Yifan Wang   +15 more
doaj   +1 more source

Hepatectomy After Conversion Therapy for Initially Unresectable HCC: What is the Difference?

Journal of Hepatocellular Carcinoma, 2022
Laihui Luo,1,* Yongzhu He,1,* Guoqing Zhu,1,* Yongqiang Xiao,1 Shengjiang Song,1 Xian Ge,2 Tao Wang,3 Jin Xie,1 Wei Deng,1 Zhigao Hu,1 Renfeng Shan1 1Department of General Surgery, The First Affiliated Hospital of Nanchang, Nanchang, People’s
Luo L, He Y, Zhu G, Xiao Y, Song S, Ge X, Wang T, Xie J, Deng W, Hu Z, Shan R   +10 more
doaj  

Pathological Complete Response and Successful Conversion Hepatectomy in Initially Unresectable Giant Hepatocellular Carcinoma Following Triple Therapy With HAIC, Bevacizumab, and Tislelizumab: A Case Report

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Severe future liver remnant (FLR) deficiency frequently renders giant hepatocellular carcinoma (HCC) unresectable. We report a 48‐year‐old man with an unresectable 23.5‐cm giant HCC (Couinaud segments 4/5/8; baseline serum alpha‐fetoprotein (AFP), 1036.65 μg/L).
Qing Ye, Jiamin Wang, Junming He, Jianxin Peng, Huilan Zeng, Jiaqiang Mo   +5 more
wiley   +1 more source

Perioperative Risks of Concurrent Pancreatic and Hepatic Resections for Neuroendocrine Tumors

Journal of Surgical Oncology, Volume 134, Issue 6, Page 830-839, November 2026.
ABSTRACT Background and Objectives Pancreatic neuroendocrine tumors (pNETs) account for 1%–2% of pancreatic tumors, with an increasing incidence. The safety of concurrent pancreas‐liver resections remains uncertain. This study evaluated the national outcomes of concurrent pancreatectomy and liver‐directed surgery for pNETs. Methods ACS‐NSQIP (2019–2023)
Amir Ebadinejad, Ashrita Raghuram, Sophia Xiao, Ethan Angle, Hassan Aziz   +4 more
wiley   +1 more source

Hepatic inflow modulation with a portocaval shunt stabilizes hepatic hemodynamics and enhances liver regeneration after extended hepatectomy in a porcine model

Scientific Reports
Posthepatectomy liver failure due to small-for-size and flow (SFSF) syndrome is linked to high morbidity and mortality, with hepatic inflow modulation potentially promoting liver regeneration and mitigating SFSF-induced damage.
Arianeb Mehrabi, Samuel Schaible, Ali Ramouz, Ehsan Aminizadeh, Elias Khajeh, Omid Ghamarnejad, Jürgen Krause, Mohammadsadegh Sabagh, Ali Majlesara, Sepehr Abbasi Dezfouli, Tanja Poth, Benjamin Goeppert, Thomas Longerich, Philipp Mayer, Mohammad Golriz   +14 more
doaj   +1 more source

Indocyanine Green Fluorescence Cholangiography With Selective Intraoperative Cholangiography: A Proposed Standard for Laparoscopic Cholecystectomy

ANZ Journal of Surgery, EarlyView.
Jaswinder S. Samra, Krishna Kotecha, Anubhav Mittal   +2 more
wiley   +1 more source

Liver Injury Repair and Regeneration: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
This review outlines the spatiotemporal framework of liver injury repair and regeneration, orchestrated by molecular signaling, multicellular niche crosstalk, metabolic reprogramming, and interorgan communication. Post‑injury regenerative cascades (initiation, proliferation, termination) rely on crosstalk between hepatocytes, Kupffer cells, hepatic ...
Mingyue Pan, Ni An, Yutian Feng, Yuelei Hu, Chongqin Pan, Yuxin Su, Yuanzheng Huang, Tanqing Long, Qi Wang, Qingru Song, Pengfei Li, Xiaomeng Li, Wenzhen Yin, Zhiyuan Hu, Xiaoxuan Liu, Juan Liu   +15 more
wiley   +1 more source