Results 71 to 80 of about 7,385,684 (193)

Long-term survival after post-hepatectomy liver failure for colorectal liver metastases [PDF]

HPB, 2019
While post-hepatectomy liver failure (PHLF) accurately predicts short-term mortality, its role in prognosticating long-term overall survival (OS) remains unclear.Patients who underwent hepatectomy for colorectal liver metastases (CRLM) after portal vein embolization during 1999-2015 were evaluated retrospectively.
Katharina, Joechle, Claire, Goumard, Eduardo A, Vega, Masayuki, Okuno, Yun-Shin, Chun, Ching-Wei D, Tzeng, Jean-Nicolas, Vauthey, Claudius, Conrad   +7 more
openaire   +2 more sources

Regenerative and Hepatotropic Properties of GLP-1 and GLP-2: Mechanistic Insights and Implications for Post-Hepatectomy Liver Regeneration: A Narrative Review

Livers
Background: Liver regeneration after hepatectomy is critical for recovery, yet post-hepatectomy liver failure (PHLF) remains a significant challenge.
Ahmad Mahamid, Aasem Abu Shtaya, Saif Abu Mouch, Riad Haddad, Abdel-Rauf Zeina, Fadi Abu Baker   +5 more
doaj   +1 more source

Liver venous deprivation for resection of advanced hilar cholangiocarcinoma—a case report and review of the literature

Exploration of Targeted Anti-tumor Therapy, 2022
Hilar cholangiocarcinoma is a rare primary malignancy associated with a dismal prognosis. Currently, complete extended right or left-sided hepatectomy is the primary curative therapy.
Radoslava Stoyanova, Helmut Kopf, Wolfgang Schima, Wolfgang Karl Matzek, Alexander Klaus   +4 more
doaj   +1 more source

Clinical Translation of Patient‐Derived Organoids: Perspectives for Personalized Therapy in Cancer

International Journal of Cancer, EarlyView.
ABSTRACT Patient‐derived organoids (PDO) are accelerating precision medicine. These biological platforms allow for the autologous in vitro expansion of material from cancer patients in a considerably short period of time. These three‐dimensional models can faithfully recapitulate aspects of tissue heterogeneity, architecture, and relevant cellular ...
Haiyan Yue, Daniele Carchidi, Philipp Schmucker, Roland Seiler, Bernhard Kiss, Catarina Macedo‐Silva, Marianna Kruithof‐de Julio   +6 more
wiley   +1 more source

Retrohepatic Vena Cava Encirclement, as Surrogate of Extensive Liver Manipulation During Caval Sparing Hepatectomy, Is a Risk Factor for Tumor Recurrence After Liver Transplantation for Hepatocellular Carcinoma

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction In liver transplantation (LT) with a caval sparing (CS) approach, the presence of complete encirclement of inferior vena cava (IVC‐E) by hypertrophic segment 1 increases the technical complexity of hepatectomy. Thus, in LT for hepatocellular carcinoma (HCC), It may be suspected that the resulting greater liver manipulation and ...
Riccardo Pravisani, Claudio Bosio, Grazia Conte, Alex Borin, Amedeo Carraro, Federico Mocchegiani, Maria De Martino, Marco Vivarelli, Dario Lorenzin, Umberto Baccarani   +9 more
wiley   +1 more source

Case Report: Making room for radicality: balancing liver reserve and oncologic clearance in hilar cholangiocarcinoma through portal vein embolisation

Frontiers in Surgery
Hilar cholangiocarcinoma frequently necessitates extended hepatectomy to achieve oncological clearance, yet the risk of post-hepatectomy liver failure (PHLF) remains a critical concern when the future liver remnant (FLR) is inadequate.
Elvin Jia Hong Lee, Zhun Shen Tan, Azlanudin Azman, Isa Azzaki Zainal, Muhammad Zahid Abdul Muien, Ian Chik   +5 more
doaj   +1 more source

Risk factors for hepatic insufficiency after major hepatectomy in non-cirrhotic patients

Asian Journal of Surgery, 2019
Summary: Background: Although recent advances in surgical techniques and perioperative management have reduced the morbidity and mortality after hepatectomy, hepatic insufficiency after major hepatectomy remains an important concern. This study aimed to
Yoshiro Fujii, Atsushi Nanashima, Masahide Hiyoshi, Naoya Imamura, Koichi Yano, Takeomi Hamada   +5 more
doaj   +1 more source

Effectiveness of Albumin-bilirubin Score as a Predictor of Post-hepatectomy Liver Failure in Patients with Hepatocellular Carcinoma

The Korean Journal of Gastroenterology, 2021
Backgrounds/Aims: Post-hepatectomy liver failure (PHLF) is a major concern for patients with hepatocellular carcinoma (HCC) who have undergone liver resection. The albumin-bilirubin (ALBI) score is a novel model for assessing liver function.
Hyun Joon Park, Kwang Il Seo, Sung Jun Kim, Sang Uk Lee, Byung Cheol Yun, Byung Hoon Han, Dong Hoon Shin, Young Il Choi, Hyung Hwan Moon   +8 more
doaj   +1 more source

Post-hepatectomy liver failure.

Hepatobiliary surgery and nutrition, 2014
Hepatectomies are among some of the most complex operative interventions performed. Mortality rates after major hepatectomy are as high as 30%, with post-hepatic liver failure (PHLF) representing the major source of morbidity and mortality. We present a review of PHLF, including the current definition, predictive factors, pre-operative risk assessment,
Rondi, Kauffmann, Yuman, Fong
openaire   +1 more source

BMI1 Overexpression Alleviates Metabolic Syndrome‐Related Liver Injury by Inhibiting the Activation of the METTL3/AHNAK Axis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Abnormal protein levels have been demonstrated to contribute to the progression of various diseases, including metabolic syndrome (MetS). Here, we speculated that the downregulation of BMI1 might lead to the failure of METTL3 degradation and contribute to METTL3 overexpression in MetS‐related liver injury.
Yun‐Jiang Chen, Bei Song, Kai‐Yu Cai, Yue‐Ling Du, Yan‐Chun Gong   +4 more
wiley   +1 more source