Results 31 to 40 of about 6,606,497 (285)

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Biologics for Inflammatory Bowel Disease in Clinical Practice: A Calabria (Southern Italy) Prospective Pharmacovigilance Study

Pharmaceutics, 2022
Background: The use of immune-modifying biological agents has markedly changed the clinical course and the management of Inflammatory bowel diseases (IBDs).
Martina Tallarico, Caterina Palleria, Livia Ruffolo, Rocco Spagnuolo, Maria Diana Naturale, Adele Emanuela De Francesco, Caterina De Sarro, Rossella Romeo, Rita Citraro, Patrizia Doldo, Ludovico Abenavoli, Luca Gallelli, Francesco Luzza, Antonio Leo, Giovambattista De Sarro   +14 more
doaj   +1 more source

Data‐Driven Materials Science for Energy‐Sustainable Applications

Advanced Materials, EarlyView.
Data‐driven approaches powered by artificial intelligence are transforming materials discovery for energy sustainability. This review examines how auto‐generated high‐quality materials databases and domain‐specific language models accelerate research in photovoltaics, thermoelectrics, batteries and magnetic materials. Applications involve extraction of
Jacqueline M. Cole
wiley   +1 more source

Safety and effectiveness of oral blonanserin for schizophrenia: A review of Japanese post-marketing surveillances

Journal of Pharmacological Sciences, 2021
Schizophrenia significantly limits social functioning with positive and negative symptoms and cognitive dysfunction. Blonanserin (LONASEN®), a novel second-generation antipsychotic approved for treating schizophrenia in Japan in 2008, reportedly shows ...
Yoshifumi Inoue, Kimiko Tsuchimori, Hiroshi Nakamura   +2 more
doaj   +1 more source

Advanced Materials for Biologics Delivery to Brain Tumors

Advanced Materials, EarlyView.
Material innovation is central to unlocking the therapeutic potential of biologics against many central nervous system diseases, including brain cancer. By engineering carriers with controlled transport, targeting, and release properties, advanced materials can overcome the blood–brain barrier and tumor microenvironment, improving the delivery of ...
Yuran Feng, Yuxue Cao, Maria Kavallaris, Taskeen Janjua, Amirali Popat   +4 more
wiley   +1 more source

A Machine Learning-Aided Framework to Predict Outcomes of Anti-PD-1 Therapy for Patients With Gynecological Cancer on Incomplete Post-Marketing Surveillance Dataset

IEEE Access, 2021
Post-marketing surveillance of antineoplastic agents is performed to evaluate the efficacy and safety in patients aiming at expanding drug indications and discovering potential adverse events.
Xiaomei Liu, Zhifeng Xiao, Yang Song, Ruizhe Zhang, Xiuqin Li, Zhenhua Du   +5 more
doaj   +1 more source

Nicotinamide Metabolism Constrains Memory CD8+ T Cell Formation Through a Putative HS1BP3‐SIRT1‐FOXO3‐BCL6 Axis

Advanced Science, EarlyView.
ABSTRACT Memory T cells exhibit long‐term persistence, a defining feature that underpins durable clinical responses to adoptive immunotherapies. The mechanisms that integrate metabolic cues with transcriptional control of memory fate remain undetermined. Here, we identify HS1‐binding protein 3 (HS1BP3) is preferentially expressed in memory CD8+ T cells.
Siyang Wang, Xiaoqian Fan, Yifan Huang, Chang Yao, Jixing Fan, Yu Ping, Xuan Zhao, Congcong Li, Chunyi Shen, Jiqi Shan, Jinyan Liu, Shengdian Wang, Zhen Zhang, Yi Zhang   +13 more
wiley   +1 more source

The 'named person': surveillance and the wellbeing of children and young people in Scotland. [PDF]

, 2015
The Scottish Parliament’s ‘Children and Young People’ Bill has extended statutory responsibilities for the welfare of children to include their well-being.
Stoddart, Eric
core   +1 more source

The consequences of drug misuse on post-marketing surveillance [PDF]

Expert Review of Clinical Pharmacology, 2016
Fabrizio Schifano, Gabriele Duccio Papanti, Laura Orsolini & John Martin Corkery, Editorial, 'The consequences of drug misuse on post-marketing surveillance', Expert Review of Clinical Pharmacology, Vol. 9 (7): 867-871, April 2016, doi: http://dx.doi.org/10.1080/17512433.2016.1178571. Published by Taylor & Francis.
Fabrizio, Schifano, Gabriele Duccio, Papanti, Laura, Orsolini, John Martin, Corkery   +3 more
openaire   +2 more sources

Advances in Se Wide‐Bandgap Photovoltaics and TexSe1‐x SWIR Photodiodes

Advanced Science, EarlyView.
In this review, fundamental properties and current challenges in Se photovoltaics (PVs) for tandem and indoor PVs and TexSe1‐x alloys for short wave infrared photodiodes are discussed. A case is made for the practicality of elemental chalcogenide optoelectronics, and a pathway toward resolving the key challenges in these respective technologies is ...
Adam D. Alfieri, Deep Jariwala
wiley   +1 more source