Results 171 to 180 of about 231,718 (342)

An Activity‐Dependent NEPAS–PTX3 Axis Links Neurovascular and Myelin Deficits to Cognitive Impairment

Advanced Science, EarlyView.
An activity‐dependent pathway links prefrontal circuit hypoactivity to cognitive impairment. Reduced PVA–mPFC activity upregulates NEPAS, which suppresses PTX3 secretion, leading to impaired angiogenesis, myelin deficits, and memory decline. Rescue is achieved by NEPAS knockdown or chemogenetic circuit activation.
Boya Hu, Zifei Chen, Bingmei Sun, Jiale Gao, Jiale Xu, Xiaochun Guo, Fenfei Gao, Zhongsi Wang, Jie Wu, Xiaoyu Ji, Peipei Liu, Bing Huang   +11 more
wiley   +1 more source

Peripheral Blood Regulatory T Cells and IL-6 are Associated with Cognitive Impairment After Acute Ischemic Stroke

Neuropsychiatric Disease and Treatment
Yueyue Chang,1,2 Xuke Zhang,3 Chuanqing Yu,2 Lei Zhu,1 Shiyu Sun,2 Zhongwu Sun1 1Department of Neurology, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People’s Republic of China; 2Department of Neurology, The First Hospital of ...
Chang Y, Zhang X, Yu C, Zhu L, Sun S, Sun Z   +5 more
doaj  

Advances in understanding the mitochondrial mechanisms underlying acupuncture therapy for post-stroke cognitive impairment

Frontiers in Neurology
Post-stroke cognitive impairment (PSCI) is a prevalent complication among stroke survivors. The core pathology of PSCI involves mitochondrial dysfunction.
Xiao Luo, Yuting Dong, Ziqi Chen, Yijing Jiang, Tao Chen, Liu Wu, Cheng Xie, Qinjian Dong, Xin Mu, Juan Li, Juan Li, Rongjiang Jin   +11 more
doaj   +1 more source

ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology

Advanced Science, EarlyView.
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li, Sifei Yu, Kaidong Lu, Yujie Zhang, Mingjie Dong, Yan Peng, Liang Xue, Waleed Alam, Yuxuan Shui, Yi Zhou, Wuyunhan Ma, Meng Bao, Peiming Li, Peiyi Luo, Tiezhan Lu, Jiajia Li, Kang Zhang, Yuying Wang, Shuchen Yang, Nuoya Yin, Francesco Faiola, Zilong Gao, Jingfeng Zhou, Fei Zhao, Yali He, Magdalena J. Koziol   +25 more
wiley   +1 more source

Post-stroke cognitive impairment and fatigue in patients with white matter hyperintensities. A prospective cohort study

Cerebral Circulation - Cognition and Behavior
Background: Cognitive impairment, depression, and fatigue are often neglected symptoms post-stroke. This study aimed to identify how white matter hyperintensity (WMH), a marker for cerebral small vessel disease (CSVD), is associated with post-stroke ...
Joakim Ölmestig, Viktor Frederik Idin Sørensen, Ingrid Grimsgaard, Birgitte Fagerlund, Christina Kruuse   +4 more
doaj   +1 more source

Neuroplasticity and post-stroke cognitive impairment (therapeutic possibilities)

МІЖНАРОДНИЙ НЕВРОЛОГІЧНИЙ ЖУРНАЛ, 2020
В статье представлена частота встречаемости, факторы риска, патогенетические механизмы развития когнитивных нарушений у пациентов, которые перенесли мозговой инсульт. Показана роль ней­ротрофических факторов в формировании когнитивного дефицита у постинсультных больных.
Mishchenko, V.M., Zabrodina, L.P.
openaire   +1 more source

Models and mechanisms of post-stroke dementia and cognitive impairment

Frontiers in stroke
Stroke is a leading cause of death and disability globally, with significant long-term impacts such as post-stroke cognitive impairment (PSCI). PSCI affects up to one-third of stroke survivors, substantially increasing their risk of dementia, especially ...
Romeesa Khan, Patrick Devlin, Akihiko Urayama, Rodney M. Ritzel   +3 more
semanticscholar   +1 more source

Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare

Advanced Science, EarlyView.
Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu, Haolin Fan, Minwoo Kim, Tong Zhou, Pinyi Yang, Lingdi Zhao, Yiran Wang, Ziyuan Che, Chia‐Wei Liu, Bingbing Li, Yangzhi Zhu   +10 more
wiley   +1 more source

Alzheimer's Disease Risk Factor APOE4 Exerts Dimorphic Effects on Female Bone

Advanced Science, EarlyView.
In aging bone, osteocytes accumulate neurodegenerative risk factor Apolipoprotein E (APOE). A humanized version of the Alzheimer's disease risk allele APOE4 altered the mouse bone transcriptome and proteome, with effects in female bone surpassing the brain, including bone fragility due to suppressed osteocytic maintenance of bone quality, identifying ...
Charles A. Schurman, Gurcharan Kaur, Serra Kaya, Joanna Bons, Carlos Galicia Aguirre, Qi Liu, Christina D. King, Kenneth A. Wilson, Harrison L. Baker, Mikayla Hady, Nadja Maldonado Luna, Gregor Bieri, Saul A. Villeda, Lisa M. Ellerby, Birgit Schilling, Tamara Alliston   +15 more
wiley   +1 more source

Systemic immune-inflammation index upon admission correlates to post-stroke cognitive impairment in patients with acute ischemic stroke

Aging
Background: The purpose of this prospective study was to evaluate the association of systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), with PSCI in patients with acute ischemic stroke (AIS).
Yongqing Cheng, Honghong Zhu, Changxia Liu, Lei Li, Fangjia Lin, Yan Guo, Cong Gu, Dingming Sun, Yang Gao, Guojun He, Shifu Sun, Shouru Xue   +11 more
semanticscholar   +1 more source