Results 251 to 260 of about 571,207 (361)

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

3D Multicellular Scaffold Based Model for Advancing Bone Disorder Research

Advanced Functional Materials, EarlyView.
A scalable 3D multicellular in vitro bone model engineered by integrating osteoblasts, osteoclasts, and endothelial cells on biodegradable scaffolds. The system recapitulates key features of human bone remodeling and disease pathology. As a proof of concept, the model mimics osteogenesis imperfecta, demonstrating its potential as a physiologically ...
Gali Guterman‐Ram, Majd Machour, Janette Zavin, Roy Meretzki, Reut Lev‐Ari, Shulamit Levenberg   +5 more
wiley   +1 more source

Comprehensive Transcriptomic and Epitranscriptomic Profiling of Hepatitis B Virus Transcripts in Two Hepatocellular Carcinoma Cell Lines. [PDF]

Genes (Basel)
Zhang Q, Zhang B, Wang L, Liu Y, Han J, Jia L, Li H, Wang X, Li J, Yu C, Li L.   +10 more
europepmc   +1 more source

Mechanically Tunable Bone Scaffolds: In Vivo Hardening of 3D‐Printed Calcium Phosphate/Polycaprolactone Inks

Advanced Functional Materials, EarlyView.
A 3D bone scaffold with osteogenic properties and capable of hardening in vivo is developed. The scaffold is implanted in a ductile state, and a phase transformation of the ceramic induces the stiffening and strengthening of the scaffold in vivo. Abstract Calcium phosphate 3D printing has revolutionized customized bone grafting.
Miguel Mateu‐Sanz, Pablo Varela, Laura del‐Mazo‐Barbara, Irene Lodoso‐Torrecilla, Emilio Jiménez‐Piqué, Jordi Franch, Miguel Alaminos, Maria‐Pau Ginebra   +7 more
wiley   +1 more source

Chromatin remodeling and epigenetic regulation in chronic kidney disease. [PDF]

Front Genet
Liang J, Wan C.
europepmc   +1 more source

DENTA: A Dual Enzymatic Nanoagent for Self‐Activating Tooth Whitening and Biofilm Disruption

Advanced Functional Materials, EarlyView.
The nanoapatite with dual enzymes (DENTA) accumulates in dentinal tubules, reducing hypersensitivity caused by dental nerve exposure and facilitating continuous ROS generation through salivary glucose for effective, long‐term whitening. The dentin structures remain non‐destructive due to the low concentration of ROS, demonstrating excellent cell ...
Junseok Kim, Dai‐Hwan Kim, Priyannth R. Sundharbaabu, Chae Yeon Lee, Jina Bae, Jiyu Hyun, Young‐Ju Jang, Haeni Kim, Min‐Ho Hong, Juewen Liu, Tobias Fey, Suk Ho Bhang, Jun Hyuk Heo, Jung Heon Lee   +13 more
wiley   +1 more source

METTL14 Promotes Lipid Synthesis in Dairy Goat Mammary Epithelial Cells by Targeting CEBPB via m6A-YTHDF1/3-Dependent Manner. [PDF]

Animals (Basel)
Jiao H, Zhu L, Tang X, Gong P, Wang W, Liu B, Luo J.   +6 more
europepmc   +1 more source

Complete list of canonical post-transcriptional modifications in the Bacillus subtilis ribosome and their link to RbgA driven large subunit assembly [PDF]

A.M. Popova, Nikhil Jain, Xiyu Dong, Farshad Abdollah-Nia, Robert A. Britton, James R. Williamson   +5 more
openalex   +1 more source

PSVII-9 Post transcriptional modifications may lead to changes in newborn goats’ skeletal muscle proteome as a consequence of maternal feed restriction at different stages of gestation

, 2020
Thaís Correia Costa, Tiago Antônio de Oliveira Mendes, Felipe Henrique de Moura, Ranyeri Souza, Marta Maria dos Santos, Mariana Mescouto Lopes, Nick V. L. Serão, Fabyano Silva, Mateus Pies Gionbelli, Márcio de Souza Duarte   +9 more
openalex   +2 more sources

Roles of post-transcriptional modifications in Solanum lycopersicum

Methylation at the N6 position of internal adenosines (m6A) is known as the most prevalent and widespread modification in mRNA. In plants, m6A has roles in post-transcriptional gene control, influencing growth, development and reproduction. The function of these modifications is often mediated by RNA binding proteins containing a YT521-B homology (YTH)
openaire