Results 241 to 250 of about 6,379,811 (286)

NSUN2-Mediated m⁵C Methylation in Human Disease: Mechanism and Therapeutic Implications. [PDF]

Int J Gen Med
Zheng X, Zhao S, Gu H, Jiang P, Zheng L.
europepmc   +1 more source

Quantum chemical profiling of the electronic structure and hydrolytic stability of modified ribonucleosides.

Phys Chem Chem Phys
Kojasoy V, Raines RT.
europepmc   +1 more source

The Emerging Biology of RNA Post-Transcriptional Modifications [PDF]

RNA Biology, 2017
RNA modifications have long been known to be central in the proper function of tRNA and rRNA. While chemical modifications in mRNA were discovered decades ago, their function has remained largely mysterious until recently. Using enrichment strategies coupled to next generation sequencing, multiple modifications have now been mapped on a transcriptome ...
Sigrid Nachtergaele, Chuan He
exaly   +3 more sources

Distribution and Frequencies of Post-Transcriptional Modifications in tRNAs [PDF]

RNA Biology, 2014
Functional tRNA molecules always contain a wide variety of post-transcriptionally modified nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with other macromolecules and fine-tune the decoding of mRNAs during translation. Their presence in functionally important regions of tRNA is conserved in all domains of life.
Magdalena A Machnicka, Janusz Bujnicki, Henri Grosjean   +2 more
exaly   +3 more sources

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RNA post-transcriptional modification speaks to chromatin

Nature Genetics, 2020
The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease.
Dalen Chan, Pedro J. Batista
openaire   +2 more sources