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Post-transcriptional nucleotide modification and alternative folding of RNA [PDF]
Nucleic Acids Research, 2006 Alternative foldings are an inherent property of RNA and a ubiquitous problem in scientific investigations. To a living organism, alternative foldings can be a blessing or a problem, and so nature has found both, ways to harness this property and ways to avoid the drawbacks.
Mark Helm
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RNA post-transcriptional modification speaks to chromatin
Nature Genetics, 2020The role of N6-methyladenosine (m6A) is still not fully understood. Two new studies advance understanding of this RNA modification. One shows that m6A modification of nascent messenger RNA promotes transcription by recruiting the histone H3 K9 demethylase KDM3B. Another study identifies genetic variants that affect m6A deposition and human disease.
Dalen Chan, Pedro J. Batista
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Post-transcriptional Modifications Modulate rRNA Structure and Ligand Interactions
Accounts of Chemical Research, 2016Post-transcriptional modifications play important roles in modulating the functions of RNA species. The presence of modifications in RNA may directly alter its interactions with binding partners or cause structural changes that indirectly affect ligand recognition.
Jun, Jiang +2 more
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Small nucleolar RNAs and RNA-guided post-transcriptional modification
Essays in Biochemistry, 2013snoRNAs (small nucleolar RNAs) constitute one of the largest and best-studied classes of non-coding RNAs that confer enzymatic specificity. With associated proteins, these snoRNAs form ribonucleoprotein complexes that can direct 2′-O-methylation or pseudouridylation of target non-coding RNAs.
Lauren, Lui, Todd, Lowe
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Traces of post-transcriptional RNA modifications in deep sequencing data
Biological Chemistry, 2011Abstract Many aspects of the RNA maturation leave traces in RNA sequencing data in the form of deviations from the reference genomic DNA. This includes, in particular, genomically non-encoded nucleotides and chemical modifications. The latter leave their signatures in the form of mismatches and conspicuous patterns of sequencing reads ...
Findeiss, Sven +3 more
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[Post-transcriptional protein modification of Gata4].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics, 2013Gata4 is an important transcription factor in heart development. Gata4 post-transcriptional protein modification regulates transcriptional activity and DNA binding, which in turn affects expression of downstream genes and transcription factors, differentiation of embryonic stem cells and cardiogenesis.
Li-Wei, Yu, Yong-Hao, Gui
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Minimal post-transcriptional modification of yeast mitochondrial ribosomal RNA
Journal of Molecular Biology, 1975Yeast mitochondrial ribosomal RNAs (21 S and 15 S) † have been analysed for methylated residues and pseudo-uridine content. Analysis of methyl-3H-labelled nucleosides in 21 S rRNA shows the presence of only two methylated residues with a molar yield of approximately one; they are presumably ribose methylated, because in 32PO4-labelled 21 S RNA two ...
J, Klootwijk, I, Klein, L A, Grivell
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Post-transcriptional Modifications Contribute to the Upregulation of Cyclin D2 in Multiple Myeloma
Clinical Cancer Research, 2016Abstract Purpose: Dysregulation of one of the three D-cyclin genes has been observed in virtually all multiple myeloma tumors. The mechanisms by which CCND2 is upregulated in a set of multiple myeloma are not completely deciphered. We investigated the role of post-transcriptional regulation through the interaction between miRNAs and ...
Misiewicz-Krzeminska, Irena +16 more
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RNA Processing and Other Post-Transcriptional Modifications
1982RNA molecules play a central part in cell metabolism, either by directing the synthesis of proteins or functioning as essential components of the proteinsynthesising machinery. A detailed knowledge of their structure and metabolism is, therefore, an essential pre-requisite for an understanding of the control of protein synthesis.
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Post-Transcriptional Modifications of Plant Small RNAs
2011Generally, small RNAs are generated template dependent by RNA polymerases or RNA dependent RNA polymerases with the transcription template being either DNA or RNA. Following transcription, small RNAs in plants undergo processing by Dicer-like RNase III type endonucleases to define their mature 5′ and 3′ termini. Part of the maturation process of small
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