Results 211 to 220 of about 218,971 (253)

The Role of Epigenetics in Corneal Fibrosis. [PDF]

Epigenomes
Coelho JT, Dewald EJ, Ali SR, Geary ML, Santra M, Yam GHF.   +5 more
europepmc   +1 more source

Engineering Protein Stability with Small Molecules: A Review of the ecDHFR Destabilizing Domain System. [PDF]

ACS Chem Biol
Ruhinda M, Olmo RP, Burini BC.
europepmc   +1 more source

Dual roles of lactylation modification in gastric cancer: Crosstalk between metabolic reprogramming and epigenetic regulation (Review). [PDF]

Oncol Rep
Xu Y, Wang W, Zhang Y, Fan Y, Dong W, Yang J.   +5 more
europepmc   +1 more source

RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review). [PDF]

Int J Mol Med
Liu S, Ma Z, Ji B, Zhu J, Yao S, Terai S, Tuo B, Li T, Liu X.   +8 more
europepmc   +1 more source

N6-methyladenosine modification in the context of viral infection: from molecular mechanism to therapeutic potential. [PDF]

Virus Res
Wu X, Deng Z, Li Y, Shi C.
europepmc   +1 more source

RNA Modifications in T cell Immunity: Mechanisms, Disease Relevance, and Therapeutic Potential. [PDF]

Theranostics
Zhao X, Zou M, Feng W, Li N, Chen X, Lin P, Zhou Z, Lin Y, Cui L.   +8 more
europepmc   +1 more source

The emerging biology of RNA post-transcriptional modifications [PDF]

RNA Biology, 2017
RNA modifications have long been known to be central in the proper function of tRNA and rRNA. While chemical modifications in mRNA were discovered decades ago, their function has remained largely mysterious until recently. Using enrichment strategies coupled to next generation sequencing, multiple modifications have now been mapped on a transcriptome ...
Sigrid Nachtergaële, Chuan He
exaly   +3 more sources

Post-transcriptional gene regulation by mRNA modifications [PDF]

Nature Reviews Molecular Cell Biology, 2016
The recent discovery of reversible mRNA methylation has opened a new realm of post-transcriptional gene regulation in eukaryotes. The identification and functional characterization of proteins that specifically recognize RNA N6-methyladenosine (m6A) unveiled it as a modification that cells utilize to accelerate mRNA metabolism and translation.
Boxuan Simen Zhao, Chuan He, Ian A Roundtree   +2 more
exaly   +3 more sources

Distribution and frequencies of post-transcriptional modifications in tRNAs [PDF]

RNA Biology, 2014
Functional tRNA molecules always contain a wide variety of post-transcriptionally modified nucleosides. These modifications stabilize tRNA structure, allow for proper interaction with other macromolecules and fine-tune the decoding of mRNAs during translation. Their presence in functionally important regions of tRNA is conserved in all domains of life.
Magdalena Machnicka, Janusz Bujnicki, Henri Grosjean   +2 more
exaly   +3 more sources