Results 201 to 210 of about 625,558 (252)
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RIP1 post-translational modifications
Biochemical Journal, 2022Receptor interacting protein 1 (RIP1) kinase is a critical regulator of inflammation and cell death signaling, and plays a crucial role in maintaining immune responses and proper tissue homeostasis. Mounting evidence argues for the importance of RIP1 post-translational modifications in control of its function.
Eugene Varfolomeev, Domagoj Vucic
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Applications of genetic code expansion in studying protein post-translational modification.
Journal of Molecular Biology, 2021Various post-translational modifications can naturally occur on proteins, regulating the activity, subcellular localization, interaction, or stability of the proteins. However, it can be challenging to decipher the biological implication or physiological
Jinghao Chen, Y. Tsai
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Regulation of plant peptide hormones and growth factors by post-translational modification.
Plant biology, 2018The number, diversity and significance of peptides as regulators of cellular differentiation, growth, development and defence of plants has long been underestimated.
Nils Stührwohldt, A. Schaller
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Post-translational modifications of lantibiotics
Antonie van Leeuwenhoek, 1996Several newly reported post-translational modification reactions are involved in lantibiotic biosynthesis. A short overview of the present knowledge on the post-translational modifications and on the enzymes involved in lantibiotic biosynthesis is given. The oxidative decarboxylation of the epidermin precursor peptide EpiA is described in detail.
T, Kupke, F, Götz
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Allosteric post-translational modification codes
Trends in Biochemical Sciences, 2012Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites.
Ruth, Nussinov +3 more
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Post-translational Modification in Muscular Dystrophies
2022Muscular dystrophies are a complex group of inherited neuromuscular disorders that progressively lead to a loss of muscle fibers and mobility and muscle weakness; over time, they evolve to an increasing level of disability. Muscular dystrophies are mostly caused by genetic mutations in proteins responsible for maintaining sarcolemma structures, such as
Sandonà M., Saccone V.
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Post-Translational Modifications
1982During the past three decades there have been major improvements in the techniques for isolating and characterizing proteins. As a consequence of the application of these improved procedures it has become apparent that proteins are not simple linear polymers of amino acids but have three–dimensional structure. Many proteins consist of several component
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Post-translational modifications and chromatin dynamics
Essays in Biochemistry, 2019Abstract The dynamic structure of chromatin is linked to gene regulation and many other biological functions. Consequently, it is of importance to understand the factors that regulate chromatin dynamics. While the in vivo analysis of chromatin has verified that histone post-translational modifications play a role in modulating DNA ...
Thomas O. Tolsma, Jeffrey C. Hansen
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Post-translational Modifications of Centromeric Chromatin
2017Regulation of chromatin structures is important for the control of DNA processes such as gene expression, and misregulation of chromatin is implicated in diverse diseases. Covalent post-translational modifications of histones are a prominent way to regulate chromatin structure and different chromatin regions bear their specific signature of histone ...
García del Arco, Ana, Erhardt, Sylvia
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Post-translational Modifications in Parkinson’s Disease
2022Parkinson's disease (PD) is a complex neurodegenerative disorder characterised by progressive degeneration of the dopaminergic neurons in the substantia nigra leading to severe motor complications. The etiology of the disease is unknown with its sporadic form accounting for 90% of cases.
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