Results 151 to 160 of about 81,942 (295)

SUMOylation is a Translatable Target in Hypoxic MNPs Regulating Retinal Vasculopathy

Advanced Science, EarlyView.
During ischemic retinopathy/retinal vasculopathy, UBC9‐mediated SUMOylation in retinal macrophages enhances their pro‐angiogenic capacity via hypoxia‐induced SUMOylation of FUS at K327/K502. This modification suppresses FUS binding to the Vegfa mRNA 3’UTR, stabilizing transcripts and facilitating VEGFA production. Targeting UBC9 inhibition can serve as
Zheng Zhong, Guangyu Liang, Huimin Yu, Jiaqi Li, Ruohong Wang, Xiaohong Ma, Ziqing Zhou, Yin Zhao, Fei Sun, Xufang Sun   +9 more
wiley   +1 more source

Ubiquitin-Like Post-Translational Modifications (Ubl-PTMs): Small Peptides with Huge Impact in Liver Fibrosis [PDF]

, 2019
Sofía Lachiondo‐Ortega, María Mercado-Gómez, Marina Serrano‐Maciá, Fernando Lopitz‐Otsoa, TANYA B. SALAS-VILLALOBOS, Marta Varela‐Rey, Teresa C. Delgado, María Luz Martínez‐Chantar   +7 more
openalex   +3 more sources

STRAP PTM: Software Tool for Rapid Annotation and Differential Comparison of Protein Post‐Translational Modifications [PDF]

, 2013
J. L. Spencer, Vivek Bhatia, Stephen A. Whelan, Catherine E. Costello, Mark E. McComb   +4 more
openalex   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

Advanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou, Keyun Li, Xiezong Hu, Shuhao Fan, Yuxuan Gao, Xiaoshu Xue, Yu Bu, Haoyi Zhang, Yili Wang, Chunjiao Wei, Shangrong Zhang, Zhongwen Xie, Chao Liu, Peng Chen, Zongjun Yin, Dalong Ren   +15 more
wiley   +1 more source

Artificial Intelligence Transforming Post-Translational Modification Research

Bioengineering
Post-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones.
Doo Nam Kim, Tianzhixi Yin, Tong Zhang, Alexandria K. Im, John R. Cort, Jordan C. Rozum, David Pollock, Wei-Jun Qian, Song Feng   +8 more
doaj   +1 more source

The novel E3 ligase of PPAR?? TRIM25 regulates adipocyte differentiation [PDF]

, 2018
Department of Biological SciencesPeroxisome proliferator-activated receptor ?? (PPAR??) is a ligand-dependent transcription factor which regulates glucose homeostasis and adipocyte differentiation.
Lee, Jae Min
core  

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Deciphering a global network of functionally associated post‐translational modifications

Molecular Systems Biology, 2012
Various post‐translational modifications (PTMs) fine‐tune the functions of almost all eukaryotic proteins, and co‐regulation of different types of PTMs has been shown within and between a number of proteins.
Pablo Minguez, Luca Parca, Francesca Diella, Daniel R Mende, Runjun Kumar, Manuela Helmer‐Citterich, Anne‐Claude Gavin, Vera van Noort, Peer Bork   +8 more
doaj   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability

Advanced Science, EarlyView.
In this review, recent advances in understanding the roles of plant peptide hormones in regulating growth, reproduction, and environmental adaptability are systematically summarized. It further elucidates the challenges in studying these peptides, such as their low abundance, functional redundancy, and complex signaling mechanisms, and highlights their
Xin Li, Liping Zhu, Huiqin Wang, Xin Zhou, Manhong Wang, Libei Li, Feng Liu, Jie Sun, Guanghui Xiao   +8 more
wiley   +1 more source