Results 151 to 160 of about 41,962 (282)

Targeting MGAT4A‐Mediated N‐Glycosylation as a Therapeutic Strategy to Inhibit Glioblastoma Stem Cell Invasion

open access: yesExploration, EarlyView.
ABSTRACT Glioblastoma (GBM) is the most aggressive type of primary brain tumor, and its invasive properties contribute significantly to incomplete surgical resection and tumor recurrence. Despite extensive clinical efforts to mitigate GBM invasion, targeted therapies against GBM stem cells (GSCs), which drive invasion, remain incompletely understood ...
Rui Niu   +3 more
wiley   +1 more source

Phloretin Suppresses Preadipocyte Differentiation by Targeting PPARγ/Transferrin to Activate Ferroptosis Signaling Pathway

open access: yesFood Frontiers, EarlyView.
Phloretin alleviates HFD‐induced obesity and suppresses adipogenesis by activating the ferroptosis pathway, potentially via targeting PPARγ and transferrin. ABSTRACT Phloretin, a plant‐derived dihydrochalcone bioactive compound, potentially modulates preadipocyte differentiation, although this remains controversial and requires further clarification ...
Jie Li   +8 more
wiley   +1 more source

A personal 360° view of applications of ‘biomimetic’ molecular recognition

open access: yesJournal of Chemical Technology &Biotechnology, EarlyView.
Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley   +1 more source

Large Scale Purification and Characterization of A21 Deamidated Variant-Most Prominent Post Translational Modification (PTM) for Insulins Which Is Widely Observed in Insulins Pharmaceutical Manufacturing [PDF]

open access: green, 2020
Vibhava Shukla   +8 more
openalex   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

open access: yesJournal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori   +9 more
wiley   +1 more source

Human Breast Milk‐Derived Exosomal FP671120.4 Inhibits Macrophage M1 Polarization via Modulating the ELAVL1/Nrf2 Axis in Sepsis‐Associated Liver Injury

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Sepsis‐associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have shown that human breast milk‐derived exosomes (HBM‐Exos) regulate processes involved in macrophage ...
Zhao‐Bin Yang   +3 more
wiley   +1 more source

PRMT5 Mediates Sepsis‐Associated Lung Injury by Modulating JAK1 Arginine Methylation: A Mechanism Study

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Lung injury is a common complication in critical sepsis. PRMT5 is implicated in endothelial inflammation and lung diseases, but its role in sepsis‐associated lung injury remains unclear. This study collected clinical sepsis samples and detected the mRNA expression of PRMT5.
Bo Wang, Zhen Ge, Fei‐Xiang Chen
wiley   +1 more source

Recent Advancements in the Characterization of D‐Amino Acid and Isoaspartate Post‐Translational Modifications

open access: yesMass Spectrometry Reviews, EarlyView.
ABSTRACT One of the great triumphs of mass spectrometry‐based peptide and protein characterization is the characterization of their modifications as most modifications have a characteristic mass shift. What happens when the modification does not change the mass of the peptide?
Samuel Okyem, Jonathan V. Sweedler
wiley   +1 more source

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