Results 141 to 150 of about 43,191 (287)
HIRA defines early replication initiation zones independently of their genome compartment
Nature CommunicationsChromatin states and 3D architecture have been used as proxy to identify replication initiation zones (IZs) in mammalian cells, yet their functional interconnections remain a puzzle.
Tina Karagyozova +7 more
doaj +1 more source
Interdisciplinary Medicine, EarlyView.This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu +6 more
wiley +1 more source
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Artificial Intelligence Transforming Post-Translational Modification Research
BioengineeringPost-Translational Modifications (PTMs) are covalent changes to amino acids that occur after protein synthesis, including covalent modifications on side chains and peptide backbones.
Doo Nam Kim +8 more
doaj +1 more source
Major peanut allergen Ara h1 and Ara h 3 epitope post-translational modifications (PTMs) [PDF]
, 2018 Objective: Peanuts are widely used for the preparation of a variety of foods and are also relied on as a protein extender. Peanut allergies affect a large portion of world population causing reactions ranging from mild to severe that can lead to anaphylaxis and even death.
Mihailović, Jelena +3 more
openaire
A personal 360° view of applications of ‘biomimetic’ molecular recognition
Journal of Chemical Technology &Biotechnology, EarlyView.Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley +1 more source
Veterinary SciencesPorcine reproductive and respiratory syndrome virus (PRRSV) is a highly contagious virus affecting pigs with significant impacts to the swine industry worldwide. This review provides a comprehensive understanding of post-translational modifications (PTMs)
Xiaoyong Chen, Jianlong Zhang
doaj +1 more source
In wound repair vimentin mediates the transition of mesenchymal leader cells to a myofibroblast phenotype. [PDF]
, 2018 Following injury, mesenchymal repair cells are activated to function as leader cells that modulate wound healing. These cells have the potential to differentiate to myofibroblasts, resulting in fibrosis and scarring.
Alnwibit, A. A. +4 more
core +1 more source
Comparative study of raw and thermally treated peanut major allergen post- translational modifications (PTMs) [PDF]
, 2019 Introduction. Peanut allergy affects a large portion of world population causing reactions rangingfrom mild to severe. Major peanut allergen IgE epitopes are well characterized but little is knownabout their post-translational modifications (PTM) and how they are affected by thermaltreatment.
Mihailović, Jelena +3 more
openaire +1 more source
The FASEB Journal, 2019 BRCA1 C‐terminal (BRCT) domains are protein binding modules that relay signals throughout various cellular pathways. The human genome encodes 23 BRCT‐domain containing proteins that are commonly found in tandem and have been characterized as phosphoprotein binding domains with functions throughout the DNA damage response.
openaire +1 more source