Results 111 to 120 of about 363,545 (300)

Prevalence of post-traumatic stress disorder and associated factors among police officers in Central Gondar Zone, North West Ethiopia, 2023: institutional-based cross-sectional study

Frontiers in Psychiatry
BackgroundPost-traumatic stress disorder (PTSD) is a psychiatric disorder that follows exposure to a traumatic or stressful life event. Police officers are exposed to a number of traumatic events that put them at risk of developing post-traumatic stress ...
Biruk Adugna, Bizuneh Tesfaye, Dawed Ali, Yohannes Mirkena, Wondale Getinet   +4 more
doaj   +1 more source

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Pathophysiological pathways of post-traumatic stress disorder in relation to traumatic brain injury: An observational cross-sectional study

SAGE Open Medicine
Objective: To investigate changes in serum neuroinflammatory biomarker concentrations and associated psychopathological manifestations in individuals with post-traumatic stress disorder, taking into account the presence or absence of traumatic brain ...
Riabinina Daria, Khamidova Alina, Abramova Olga, Zorkina Yana, Reznik Alexander, Mukhin Vladimir, Cherepantsev Georgij, Melkonyan Georgy, Lytkina Karine, Pavlova Olga, Zakurazhnaya Valeria, Ushakova Valeriya, Morozova Irina, Ochneva Alexandra, Pavlov Konstantin, Andreyuk Denis, Kostyuk Georgy, Morozova Anna   +17 more
doaj   +1 more source

Factors associated with poor self-reported health within the UK military and comparisons with the general population: a cohort study [PDF]

, 2017
Objective: To investigate the self-rated health of the UK military and explore factors associated with poor self-rated health. Compare self-rated health of the military to the general population. / Design: A cohort study.
Fear, NT, Jenkins, SC, Stevelink, SAM
core  

Promotion of DFU Wound Healing via BRG1–COL16A1 Axis in Fibroblasts

Advanced Science, EarlyView.
In normal wound healing, transcription factor BRG1 is upregulated and binds the COL16A1 promoter to enhance its expression, promoting fibroblast proliferation, migration, contraction, extracellular matrix deposition, and granulation tissue formation, thus accelerating wound closure.
Penghui Wang, Jiaming Sun, Ying Wang, Bichen Ren, Yuxin Liu, Yunhan Liu, Liang Chen, Lu Yu, Tao Dai, Li Yu, Zhihui Dong   +10 more
wiley   +1 more source

PSYCHOLOGICAL DEBRIEFING (PD) UNTUK MENURUNKAN GEJALA POST-TRAUMATIC STRESS DISORDER (PTSD) PADA INDIVIDU MENGALAMI PERISTIWA TRAUMATIS [PDF]

Post traumatic stress disorder (PTSD) is a chronic disorder that occurs afterexperiencing a traumatic event. This disorder can result in impaired functioning of theindividual and cause disruption of daily life, such as physiological reactions, self-blame
Kinanti, Rizka Rahma
core  

Targeted H2S Delivery System Attenuates Blood‐Spinal Cord Barrier Disruption after Spinal Cord Injury by Reshaping the Ferritinophagy Pathway

Advanced Science, EarlyView.
The αvβ3‐mediated SPRC@MPDA‐RGD targets broken endothelial cells and controllably releases SPRC. CSE is then activated to produce endogenous H2S, which inhibits ferritinophagy. In brief, H2S inhibits autophagy by activating the PI3K/Akt/mTOR pathway, thereby suppressing the ferroptosis process mediated by NCOA4, and ultimately promoting the ...
Zhiheng Chen, Xinkai Pu, Ruiyang Li, Yuezhou Wu, Qirong Zhou, Jian Wang, Yuxuan Qian, Fengjie Lu, Jian‐Yuan Zhao, Zhida Su, Jiacan Su, Xiaofeng Lian   +11 more
wiley   +1 more source

Post-traumatic stress disorder in women and their partners, following severe post-partum hemorrhage: A study protocol for a prospective cohort study

Cogent Medicine, 2017
Background: Post-traumatic stress disorder is a Trauma- and Stressor-Related Disorder resulting from exposure to an event that is considered as traumatic.
Karel Willem Frank Scheepstra, Minouk Esmée van Steijn, Lea Magdalena Dijksman, Maria Gabriel van Pampus   +3 more
doaj   +1 more source

Elevated TRIM25 Impairs Poly (ADP‐ribose) Metabolism via PARG Degradation and Mediates Compression‐Induced Intervertebral Disc Degeneration

Advanced Science, EarlyView.
TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Zhangrong Cheng, Haiyang Gao, Wenbo Wu, Pengzhi Shi, Xianglong Chen, Zimu Yu, Wang Wu, Kangcheng Zhao, Cao Yang, Yukun Zhang   +9 more
wiley   +1 more source

Welfare and warfare an uneasy mix: personal experiences of and organisational responses to emotional and mental health issues in young ex-service personnel [PDF]

, 2008
'Shell-shock', which is now known as Post Traumatic Stress Disorder (PTSD), was first identified during the First World War and since this time the mental health of service personnel has been an issue of concern, particularly during times of armed ...
Green, Gill, O'Neill, Dan, Walker, Steven   +2 more
core