Results 121 to 130 of about 15,420,023 (304)

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

Considerations of post application in restoration of endodontically treated teeth: A review

open access: yesمجله دانشکده دندانپزشکی اصفهان, 2010
Using a post is a common method in providing the adequate retention for coronal restoration of endodontically treated teeth. With proper post selection, the success rate of this kind of treatment is considerable.
M Ebrahimi Dastgerdi,   +6 more
doaj  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Yet another bidirectional algorithm for shortest paths [PDF]

open access: yes
For finding a shortest path in a network the bidirectional~A* algorithm is a widely known algorithm. An A* instance requires a heuristic estimate, a real-valued function on the set of nodes.
Pijls, W.H.L.M., Post, H.
core   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Przeto, ktokolwiek by jadł chleb i pił z kielicha Pańskiego niegodnie (…) sąd własny je i pije (1 Kor 11,27-29) – czyli o właściwym przygotowaniu się do Świętej Eucharystii według nauki Ojców Kościoła

open access: yesElpis, 2014
„Sakrament Sakramentów” bądź „Misterium Misteriów”, jak nazywana jest Święta Eucharystia to rekapitulacja tajemnicy ekonomii zbawienia człowieka. Jej znaczenie, rola i waga, jako centralnego miejsca żywego organizmu Kościoła, jest niepodważalna. Wszystko
Adam Magruk
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Hledat a nalézat: Barokní Valdštejnové a jejich informační síť

open access: yesTheatrum Historiae, 2012
This article deals with the information network linking the members of the House of Waldstein, a top aristocratic dynasty in the society of the early Modern Age.
Jiří Hrbek
doaj  

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