Results 101 to 110 of about 13,226,587 (254)
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Teachers motivation and work-family conflict: perceptions of Fil-Am teachers
Acta Scientiarum. EducationThis study was undertaken to investigate the relationship between motivation and experienced work-family conflict (WFC). The sample consisted of 105 K-12 Filipino-American teachers in Maryland, USA.
Geony Provido +5 more
doaj +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
Patient Experiences and Insights on Chronic Ocular Pain: Social Media Listening Study
JMIR Formative ResearchBackgroundOcular pain has multifactorial etiologies that affect activities of daily life, psychological well-being, and health-related quality of life (QoL).
Brigitte Sloesen +7 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Ex-ante price commitment with renegotiation in a dynamic market [PDF]
This paper studies a dynamic model of a market such as a labour market in which firms post wages and search for workers but trade may occur at a negotiated wage procedure in markets characterized by match-specific heterogeneity.
Masters, Adrian, Muthoo, Abhinay
core +2 more sources
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
POSTED - general questionnaire [PDF]
, 2014 This questionnaire is concerned with carers experiences of daytime postural care. This questionnaire may be completed by anyone with experience of providing postural care to a child with a physical disability in a school and/or home environment.
Hamilton-West, K. +2 more
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Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Posted workers – for some it matters. CEPS Policy Insights No 2017/37, 26 October 2017 [PDF]
, 2017 The European Council, Parliament and Commission are about to start trilogue negotiations over the revision of the posting of workers Directive (PWD) of 1996.
Busse, Mathias +2 more
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