Results 101 to 110 of about 871,457 (367)

Determining a Role for Ventromedial Prefrontal Cortex in Encoding Action-Based Value Signals During Reward-Related Decision Making [PDF]

open access: yes, 2009
Considerable evidence has emerged to implicate ventromedial prefrontal cortex in encoding expectations of future reward during value-based decision making.
Alan N. Hampton   +53 more
core   +3 more sources

Pigment Epithelium‐Derived Factor Deficiency Impairs Hippocampal Glutamate Homeostasis and Cognitive Function by Downregulating Astrocytic GLT‐1

open access: yesAdvanced Science, EarlyView.
The chronic glutamate‐induced excitotoxicity hypothesis has profoundly informed the therapeutic strategies employed in Alzheimer’s disease (AD). This study shows pigment epithelium‐derived factor (PEDF) regulates astrocytic glutamate transporter‐1 (GLT‐1)‐mediated glutamate homeostasis and cognition. Reduced PEDF correlates with lower Mini‐Mental State
Jin‐Hui Shi   +15 more
wiley   +1 more source

Resting-state fMRI data of awake dogs (Canis familiaris) via group-level independent component analysis reveal multiple, spatially distributed resting-state networks

open access: yesScientific Reports, 2019
Resting-state networks are spatially distributed, functionally connected brain regions. Studying these networks gives us information about the large-scale functional organization of the brain and alternations in these networks are considered to play a ...
Dóra Szabó   +6 more
doaj   +1 more source

Neuroanatomical substrates for the volitional regulation of heart rate [PDF]

open access: yes, 2015
The control of physiological arousal can assist in the regulation of emotional state. A subset cortical and subcortical brain regions are implicated in autonomic control of bodily arousal during emotional behaviors.
Asmundson   +77 more
core   +2 more sources

Stimulation of the posterior cingulate impairs episodic memory encoding [PDF]

open access: yes, 2018
Neuroimaging experiments implicate the posterior cingulate cortex (PCC) in episodic memory processing, making it a potential target for responsive neuromodulation strategies outside of the hippocampal network. However, causal evidence for the role PCC plays in memory encoding is lacking.
Natu, Vaidehi S.   +5 more
openaire   +2 more sources

A Replicable and Generalizable Neuroimaging‐Based Indicator of Pain Sensitivity Across Individuals

open access: yesAdvanced Science, EarlyView.
Humans differ in their sensitivity to pain. With six large and diverse fMRI datasets (total N = 1046), this study finds that such individual differences in pain sensitivity can be tracked by fMRI responses to painful stimuli. A highly generalizable machine learning model is further built to predict pain sensitivity across all datasets and analgesic ...
Li‐Bo Zhang   +7 more
wiley   +1 more source

Neural mechanisms of rapid sensitivity to syntactic anomaly

open access: yesFrontiers in Psychology, 2013
Recent psycholinguistic models hypothesize that anticipatory processing can speed the response to linguistic input during language comprehension by pre-activating representations necessary for word recognition.
Albert E. Kim, Phillip M. Gilley
doaj   +1 more source

Altered Energy Metabolism Pathways in the Posterior Cingulate in Young Adult Apolipoprotein E ɛ4 Carriers

open access: yesJournal of Alzheimer's Disease, 2016
The APOE gene, encoding apolipoprotein E, is the primary genetic risk factor for late-onset Alzheimer’s disease (AD). Apolipoprotein E ɛ4 allele (APOE4) carriers have alterations in brain structure and function (as measured by brain imaging) even as ...
Michelle Perkins   +12 more
semanticscholar   +1 more source

Affective modulation of cognitive control is determined by performance-contingency and mediated by ventromedial prefrontal and cingulate cortex [PDF]

open access: yes, 2013
Cognitive control requires a fine balance between stability, the protection of an on-going task-set, and flexibility, the ability to update a task-set in line with changing contingencies.
Braem, Senne   +5 more
core   +1 more source

Task-dependent posterior cingulate activation in mild cognitive impairment [PDF]

open access: yesNeuroImage, 2006
Neuroimaging research has demonstrated that the posterior cingulate cortex (PCC) is functionally compromised in individuals diagnosed with amnestic mild cognitive impairment (MCI), a major risk factor for the development of Alzheimer's disease (AD). In functional MRI studies with healthy participants, this same region is active during self-appraisal ...
Sterling C. Johnson   +10 more
openaire   +5 more sources

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