Results 41 to 50 of about 7,517 (176)

Distinct effects of fibromyalgia pain, depression and anxiety on perception of affective touch and pain

The Journal of Physiology, EarlyView.
Abstract figure legend Patients with fibromyalgia (FM) and no‐pain controls completed questionnaire‐based ratings of chronic pain, childhood trauma, anxiety and depression. Brief touch stimuli were then administered, including slow brushing at the C‐tactile optimal velocity of 3 cm/s, deep oscillating pressure with a compression sleeve, roboticized ...
Benedetta Albinni, Marisa Zimmerman, Vincent Alasha, Jacob Ross, Lindsey Crankshaw, Sandy R. Hu, Nathaniel Schuster, Laura Case   +7 more
wiley   +1 more source

Efficacy and Safety of Crisugabalin for Inadequately Controlled Diabetic Peripheral Neuropathic Pain: A Randomized, Active‐Controlled, Phase 2 Trial

Diabetes, Obesity and Metabolism, Volume 28, Issue 12, Page 11946-11954, December 2026.
ABSTRACT Aims Crisugabalin (HSK16149), a selective γ‐aminobutyric acid (GABA) analog, has shown preliminary efficacy in controlling diabetic peripheral neuropathic pain (DPNP), but efficacy in patients with inadequate response to prior pregabalin treatment remains unknown. Materials and Methods This multicentre randomized controlled trial was conducted
Yaming Li, Fang Zhang, Wei Liu, Xiuhai Su, Bin Zhou, Na Xu, Junjie Shang, Chen Fang, Liujun Fu, Fangqiong Li, Chao Zheng, Jinyou Duan   +11 more
wiley   +1 more source

Co‐Delivery of Varicella Zoster Virus gE and gI Dual‐Antigen mRNA Vaccine With CpG‐ODN Elicits Robust Immunity

MedComm, Volume 7, Issue 11, November 2026.
The gE+gI Lmix+CpG‐ODN 1018 vaccine was formulated by combining gE and gI mRNA/LNPs with the TLR9 agonist adjuvant CpG‐ODN 1018. This formulation induces robust humoral and cellular immunity while maintaining a favorable safety profile and physiological stability in mice.
Lingyan Cui, Sibo Zhang, Wenhui Xue, Hongjing Liu, Hong Wang, Hai Li, Yarong Zeng, Huizheng Zhang, Yaohan Li, Minqing Hong, Lin Chen, Jun Zhang, Ying Gu, Shaowei Li, Tingting Li, Ningshao Xia   +15 more
wiley   +1 more source

Local injection of a freshly manufactured 35 kDa hyaluronan fragment reduces neuropathic and inflammatory pain: A clinical study

European Journal of Inflammation
To investigate the ability of the 35 kDa low-molecular-weight hyaluronan fragment (HA35) to relieve neuropathic and inflammatory pain, including postherpetic neuralgia and shoulder, neck, back and temporomandibular pain.
FengHe Xu, Dylan Treger, Xinyue Ma, XiaoXiao Jia, Joshua H Shofaro, Taivanbat Ganbaatar, Munkh-Amgalan Gantumur, Jessica Hui, Mizhou Hui, Chao Meng   +9 more
doaj   +1 more source

Continuous Intravenous Acyclovir as Outpatient Parenteral Antimicrobial Therapy for HSV and VZV Neurological Infections: A Case Series With Pharmacokinetic and Cost Evaluation, and Review of Literature

Reviews in Medical Virology, Volume 36, Issue 6, November 2026.
ABSTRACT Varicella zoster virus (VZV) and herpes simplex virus (HSV) are major causes of viral meningitis and encephalitis. Standard intermittent intravenous acyclovir requires hospitalisation, reducing patient comfort and prolonging admissions. Continuous infusion may maintain therapeutic plasma and cerebrospinal fluid (CSF) concentrations while ...
Irene G. Manders, Eline L. van Tuinen, Martijn Weisfelt, Marco Goeijenbier, Jayant S. Kalpoe, Steven F. L. van Lelyveld, Eric C. M. van Gorp, Ken Ho Hua   +7 more
wiley   +1 more source

Post-herpetic neuralgia

Revista Dor
BACKGROUND AND OBJECTIVES: Post-herpetic neuralgia is defined as pain persisting for more than three months after the resolution of skin eruptions observed in herpes-zoster.
Charles Amaral de Oliveira, Anita Perpétua Carvalho Rocha de Castro, Susana Abe Miyahira   +2 more
doaj   +1 more source

Sustained Delivery of a Shingles Subunit Vaccine Overcomes Age‐Related Declines in Humoral and Cellular Immunity Relative to Shingrix

Advanced Science, Volume 13, Issue 60, 28 October 2026.
Sustained delivery of a shingles subunit vaccine from an injectable polymer–nanoparticle hydrogel enhanced the potency, durability, and breadth of immune responses in aged mice while minimizing inflammatory cytokine production and reactogenicity. This strategy decouples immunogenicity from reactogenicity and offers a promising approach to improve ...
Ye Eun Song, Jerry Yan, Ben S. Ou, Olivia M. Saouaf, Noah Eckman, E. A. Appel   +5 more
wiley   +1 more source

Clinical observation on radiant shock wave in the treatment of postherpetic neuralgia

Chinese Journal of Contemporary Neurology and Neurosurgery, 2013
Objective To evaluate the effect of radiant shock wave therapy (RSWT) on postherpetic neuralgia. Methods Twenty-six cases of postherpetic neuralgia were treated with RSWT around the pain point.
Xiao-hua LIU, Yong-jun ZHENG, Wei-hao XU, Xiang-rui WANG   +3 more
doaj  

Spinal Cord Stimulation in Refractory Postherpetic Neuralgia in Portugal: A Case Report

Acta Médica Portuguesa
Postherpetic neuralgia is one of the most severe complications after herpes zoster infection. Patients who experience persistent pain despite conservative treatment may benefit from interventional therapies, such as spinal cord stimulation.
Ana Inês Silva, Margarida Barbosa, Paula Barbosa, Luís Guimarães, Armanda Gomes   +4 more
doaj   +1 more source

Foot drop in generalized herpes zoster: L5‑predominant polyradiculitis as a rare complication – a case report

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Anna Malfertheiner, Alexander Mensch, Burkhard Kreft   +2 more
wiley   +1 more source