Results 91 to 100 of about 25,471 (263)

Monthly buprenorphine depot injection (SUBLOCADE®) for opioid use disorder during pregnancy

The American Journal on Addictions, EarlyView.
Abstract Background and Objectives Untreated opioid use disorder (OUD) in pregnancy is associated with adverse obstetrical outcomes, maternal morbidity, and maternal mortality. This article will inform clinicians about the use of monthly extended‐release buprenorphine (BUP‐XR, SUBLOCADE®) to treat OUD during pregnancy and postpartum.
Melinda Ramage, Becky Bishop, Vikki Mangano, Baher Mankabady   +3 more
wiley   +1 more source

Varicella Virus Vaccine Live: A 22-Year Review of Postmarketing Safety Data

Open Forum Infectious Diseases, 2019
Background Varicella, a contagious infectious disease caused by varicella zoster virus (VZV), can result in hospitalization and, occasionally, death. Varicella virus vaccine live (VVVL [VARIVAX]) was introduced in the United States in 1995.
M. Woodward, Ann Marko, S. Galea, B. Eagel, W. Straus   +4 more
semanticscholar   +1 more source

Overview of the clinical features of cefixime [PDF]

, 1998
Third-generation cephalosporins in oral formulations have become an increasingly important first-line choice against common bacterial infections. Cefixime is one such agent, which possesses excellent efficacy against a broad spectrum of pathogens ...
Adam, Dieter
core   +1 more source

Safety and effectiveness of stiripentol in patients with Dravet syndrome: A prospective, 3‐year, postmarketing surveillance study

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.16285 Abstract Aim To conduct a postmarketing surveillance study of patients with Dravet syndrome in Japan to investigate the safety and effectiveness of long‐term, real‐world, clinical use of stiripentol (STP).
Yuki Kitamura, Hiroaki Ohyabu, Tatsuo Miura, Naomi Takei‐Masuda, Daisuke Matsui, Yushi Inoue, Yoko Ohtsuka   +6 more
wiley   +1 more source

Alternative dosing regimens for atezolizumab: an example of model-informed drug development in the postmarketing setting

Cancer Chemotherapy and Pharmacology, 2019
To determine the exposure–response (ER) relationships between atezolizumab exposure and efficacy or safety in patients with advanced non-small cell lung cancer (NSCLC) or urothelial carcinoma (UC) and to identify alternative dosing regimens.
K. Morrissey, M. Marchand, H. Patel, Rong Zhang, Benjamin Wu, H. Phyllis Chan, A. Mecke, S. Girish, J. Jin, H. Winter, R. Bruno   +10 more
semanticscholar   +1 more source

Incidence of Uveitis in Secukinumab‐treated Patients With Ankylosing Spondylitis: Pooled Data Analysis From Three Phase 3 Studies

ACR Open Rheumatology, 2020
Objective The objective of this study was to report the incidence of uveitis in secukinumab‐treated patients with ankylosing spondylitis (AS) in a pooled analysis of three phase 3 trials (MEASURE 1‐3 [ClinicalTrials.gov identifiers NCT01358175 ...
Atul A. Deodhar, Corine Miceli‐Richard, Xenofon Baraliakos, Helena Marzo‐Ortega, Dafna D. Gladman, Ricardo Blanco, Ayan Das Gupta, Ruvie Martin, Jorge Safi Jr, Brian Porter, Abhijit Shete, James T. Rosenbaum   +11 more
doaj   +1 more source

Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of focal seizures

Epilepsia, EarlyView.
Abstract Objective In traditionally designed randomized clinical trials of antiseizure medications, participants take a blinded treatment for a prespecified number of weeks, irrespective of continued seizures. The alternative design time to prerandomization monthly seizure count (T‐PSC) allows participants to end the blinded treatment after an ...
Wesley T. Kerr, Leock Y. Ngo, Liang Zhu, Anna Patten, Jocelyn Y. Cheng, Lavanya Biju, Jacqueline A. French   +6 more
wiley   +1 more source

Analysis of postmarketing safety data for proton-pump inhibitors reveals increased propensity for renal injury, electrolyte abnormalities, and nephrolithiasis

Scientific Reports, 2019
Proton pump inhibitors, PPIs, are widely prescribed and sold globally. Although initially intended for time-limited treatment of acute disorders, such as gastric ulcers and esophagitis, PPIs are now commonly used for prolonged durations and are ...
T. Makunts, Isaac V. Cohen, L. Awdishu, R. Abagyan   +3 more
semanticscholar   +1 more source

Postmarketing safety of migraine prophylactic monoclonal antibodies: An EudraVigilance database analysis of eptinezumab, fremanezumab, galcanezumab, and erenumab

Headache: The Journal of Head and Face Pain, EarlyView.
Abstract Objectives/Background This study was undertaken to evaluate the postmarketing safety of monoclonal antibodies (mAbs) targeting the calcitonin gene‐related peptide pathway used for migraine prophylaxis through pharmacovigilance data analysis by examining suspected adverse events reported in Europe.
Victoria Nikitina, Greta Santi Laurini, Nicola Montanaro, Domenico Motola   +3 more
wiley   +1 more source

The Effectiveness and Safety Profile of Nivolumab‐Plus‐Ipilimumab in Previously Untreated Japanese Patients With Advanced or Metastatic Renal Cell Carcinoma (J‐ENCORE Study)

International Journal of Urology, EarlyView.
ABSTRACT Objectives Combination therapy of nivolumab‐plus‐ipilimumab has been approved for advanced or metastatic renal cell carcinoma in Japan, but large‐scale clinical data targeting Japanese patients is limited. To evaluate the early outcomes and factors related to early progression and response.
Koshiro Nishimoto, Go Kimura, Tomokazu Sazuka, Shuzo Hamamoto, Masahiro Nozawa, Kazuyuki Numakura, Atsushi Mizokami, Tsunenori Kondo, Sei Naito, Takashige Abe, Kojiro Ohba, Masayoshi Nagata, Shunta Onodera, Hiroaki Ito, Hirotsugu Uemura   +14 more
wiley   +1 more source